{"id":"W4385827818","doi":"10.1080/14737175.2023.2246653","title":"The advances in the early and accurate diagnosis of Creutzfeldt–Jakob disease and other prion diseases: where are we today?","year":2023,"lang":"en","type":"review","venue":"Expert Review of Neurotherapeutics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, British Columbia","keywords":"Chronic wasting disease; Disease; Prion protein; Medicine; Diagnostic test; Diagnostic accuracy; Diffusion MRI; Pathology; Pediatrics; Magnetic resonance imaging; Internal medicine; Scrapie; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002857785,0.0008148549,0.001439258,0.00154513,0.0003059658,0.001435004,0.0009511037,0.002446946,0.004499595],"category_scores_gemma":[0.00515835,0.0002604334,0.0009213036,0.0009387016,0.001160454,0.003089077,0.000771831,0.003891967,0.003099614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009354982,"about_ca_system_score_gemma":0.001486315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001380601,"about_ca_topic_score_gemma":0.001987484,"domain_scores_codex":[0.9989391,0.0002909884,0.0001634822,0.0001854876,0.0003364603,0.00008456163],"domain_scores_gemma":[0.9954759,0.001854554,0.0005163589,0.0000920589,0.001866287,0.0001947387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002041822,0.00004733081,0.000981662,0.01461614,0.0001705783,0.0008097526,0.0001641378,0.000276778,0.003412279,0.005394102,0.1191882,0.8547348],"study_design_scores_gemma":[0.00004181653,0.0001814852,0.002266522,0.009229516,0.0002511372,0.00472072,0.0002204818,0.00028915,0.00151136,0.007710178,0.9734987,0.00007879737],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003924181,0.9784507,0.001095613,0.0158865,0.002553914,0.000009804226,0.00005795756,0.00004101142,0.001512174],"genre_scores_gemma":[0.004027404,0.9819844,0.001486452,0.00671269,0.004697213,0.00001400576,0.0001149414,0.00001493262,0.0009478714],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004499595,"threshold_uncertainty_score":0.01511359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05176707101361117,"score_gpt":0.3839778270699959,"score_spread":0.3322107560563847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}