{"id":"W4385832385","doi":"10.2139/ssrn.4538097","title":"Development of Lm-41 and Af-2112, Two Flufenamic Acid-Derived Tead Inhibitors Obtained Through the Replacement of the Trifluoromethyl Group by Aryl Rings","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Fungal Plant Pathogen Control","field":"Agricultural and Biological Sciences","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Université du Québec à Montréal","funders":"","keywords":"Trifluoromethyl; Flufenamic acid; Aryl; Group (periodic table); Mathematics; Stereochemistry; Chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003169268,0.0004167754,0.0005963332,0.00003024212,0.0004976909,0.00008320617,0.00107422,0.0002335252,0.00002194689],"category_scores_gemma":[0.0001733395,0.000136796,0.0003095052,0.0003437444,0.0001768823,0.00009520592,0.0007493644,0.002407696,0.000003523503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004807608,"about_ca_system_score_gemma":0.000539269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003472258,"about_ca_topic_score_gemma":0.00350583,"domain_scores_codex":[0.9960347,0.0002867687,0.001003372,0.0005270547,0.000732446,0.001415623],"domain_scores_gemma":[0.9981282,0.0003358595,0.001136983,0.0002019817,0.0001232338,0.00007370063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001807159,0.00008270344,0.00118468,0.00002966958,0.0003423755,0.00000124954,0.0005422003,0.00001549551,0.9858325,0.000558547,0.0002770911,0.01095278],"study_design_scores_gemma":[0.007381686,0.003509458,0.06023256,0.002148177,0.001086063,0.0006458853,0.02483204,0.0004243588,0.7609258,0.120096,0.01554622,0.003171748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915384,0.004744629,0.0001090636,0.002246385,0.000412116,0.0007571308,0.0001037919,0.00003676249,0.00005173802],"genre_scores_gemma":[0.9973137,0.001617812,0.0001850984,0.00008656331,0.0002416888,0.00004743636,0.00006243065,0.000007041755,0.0004382775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2249067,"threshold_uncertainty_score":0.9998938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360783534246884,"score_gpt":0.2209754020503528,"score_spread":0.2073675667078839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}