{"id":"W4385835001","doi":"10.3390/metabo13080947","title":"Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Centre for Phenogenomics; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; University of California, Davis; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; Centers for Disease Control and Prevention","keywords":"Phenotype; Metabolome; Biology; Gene; Metabolomics; Sexual dimorphism; Wild type; Gene knockout; Genotype; Genetics; Metabolism; Knockout mouse; Metabolic pathway; Endocrinology; Bioinformatics; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003159657,0.0004523988,0.0003596794,0.001139433,0.0001749159,0.0003749784,0.0002103312,0.0003490296,0.001753335],"category_scores_gemma":[0.0002882322,0.000255586,0.0004080241,0.0003628591,0.0003659574,0.0001542524,0.0004133695,0.0005494423,0.0004230302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001807826,"about_ca_system_score_gemma":0.000159319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003768295,"about_ca_topic_score_gemma":0.0007869791,"domain_scores_codex":[0.9995205,0.00005552954,0.00006220954,0.0001290037,0.0001624879,0.00007019973],"domain_scores_gemma":[0.9995776,0.00005816698,0.0001818215,0.00005426746,0.00003376923,0.00009438553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001124053,0.00001429639,0.001457448,0.00001169405,0.00001089358,0.00007576428,0.00001360304,0.00001389081,0.9973817,0.00003978335,0.00002099532,0.0008474833],"study_design_scores_gemma":[0.00002806173,0.0003534029,0.1258904,0.00001497813,0.00007460111,0.002345003,0.00007186412,0.0004517929,0.8681243,0.0001916863,0.0024299,0.00002400892],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926369,0.0005758174,0.003490321,0.0001069879,0.00001591893,0.00002174588,0.002176145,0.0001332283,0.0008428232],"genre_scores_gemma":[0.9870152,0.0008838885,0.004721315,0.0001804225,0.000009392551,0.0001163658,0.003697327,0.0001975835,0.003178358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001753335,"threshold_uncertainty_score":0.005865455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409801329108154,"score_gpt":0.2326244978459427,"score_spread":0.2185264845548612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}