{"id":"W4385835001","doi":"10.3390/metabo13080947","title":"Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines","year":2023,"lang":"en","type":"article","venue":"Metabolites","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Centre for Phenogenomics; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute of Environmental Health Sciences; University of California, Davis; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; Centers for Disease Control and Prevention","keywords":"Phenotype; Metabolome; Biology; Gene; Metabolomics; Sexual dimorphism; Wild type; Gene knockout; Genotype; Genetics; Metabolism; Knockout mouse; Metabolic pathway; Endocrinology; Bioinformatics; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003402924,0.0002396484,0.0005432602,0.0001130535,0.00009497179,0.0000113027,0.0003547734,0.0001198779,0.00005005068],"category_scores_gemma":[0.0004397997,0.0001504266,0.000154141,0.0006334322,0.0002348546,0.000005210888,0.0002865287,0.00009230618,0.000007926968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004729709,"about_ca_system_score_gemma":0.00006159883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003941371,"about_ca_topic_score_gemma":0.00002995327,"domain_scores_codex":[0.9985588,0.0001017373,0.0003756062,0.0003507384,0.0002899792,0.0003231765],"domain_scores_gemma":[0.998798,0.00005350915,0.0003175073,0.0005315732,0.0002502825,0.000049095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004853104,0.00008597218,0.01226786,0.00002377795,0.0007819451,6.842091e-7,0.0001525546,0.00004623691,0.9842566,0.0005660547,0.00137178,0.0003979731],"study_design_scores_gemma":[0.0006117911,0.0001316863,0.04100516,0.000006244229,0.0002188669,0.000001488072,0.0001320005,0.00004122883,0.9432275,0.0001271119,0.01431585,0.000181111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936728,0.005076087,0.00002657337,0.0001812096,0.0001509993,0.0001898605,0.0004247824,0.00002400153,0.0002536947],"genre_scores_gemma":[0.9932717,0.001017048,0.0004763459,0.00009808242,0.0001375224,0.00002445894,0.0001042083,0.00003704699,0.004833587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04102917,"threshold_uncertainty_score":0.613422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409801329108154,"score_gpt":0.2326244978459427,"score_spread":0.2185264845548612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}