{"id":"W4385838319","doi":"10.1038/s41380-023-02123-x","title":"Polygenic contributions to performance on the Balloon Analogue Risk Task","year":2023,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"U.S. National Library of Medicine; National Institute of Dental and Craniofacial Research; National Institute on Drug Abuse; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health","keywords":"Schizophrenia (object-oriented programming); Bipolar disorder; Major depressive disorder; Psychiatry; Genetic architecture; Genome-wide association study; Endophenotype; Psychiatric genetics; Medicine; Multifactorial Inheritance; Cannabis; Schizoaffective disorder; Psychology; Clinical psychology; Single-nucleotide polymorphism; Psychosis; Genetics; Quantitative trait locus; Biology; Population; Genotype; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001631424,0.0005805715,0.0004385802,0.0006310305,0.0003966466,0.0007080947,0.0004040562,0.0005220327,0.002800593],"category_scores_gemma":[0.00522692,0.0002090566,0.0005091492,0.0008275447,0.0004522447,0.0002482734,0.0006217507,0.0006826122,0.0002262296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001511086,"about_ca_system_score_gemma":0.0001510864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004451128,"about_ca_topic_score_gemma":0.003325764,"domain_scores_codex":[0.9988404,0.0005072969,0.00006664837,0.0003644107,0.0001246755,0.00009657972],"domain_scores_gemma":[0.9968299,0.001485086,0.0007176647,0.0005450653,0.0001658806,0.0002564504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001365288,0.0001425493,0.9787608,0.0000330953,0.0008160073,0.0002906545,0.0003320187,0.001000968,0.01027802,0.0003784669,0.000470339,0.006131774],"study_design_scores_gemma":[0.00001601456,0.0001057484,0.9974421,0.000005644316,0.00009037869,0.0001877058,0.00003645543,0.00130138,0.0003271893,0.0003420299,0.0001345747,0.00001071851],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983012,0.00005602322,0.0007157591,0.00003815394,0.000004464122,0.000006358099,0.0006350222,0.00001306871,0.0002299271],"genre_scores_gemma":[0.9986607,0.00002205021,0.000440686,0.00001264647,0.000005028752,0.00001371439,0.0006410265,0.00001111024,0.0001930515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004451128,"threshold_uncertainty_score":0.009368896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006135512116254935,"score_gpt":0.2581537167924638,"score_spread":0.2520182046762089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}