{"id":"W4385851459","doi":"10.1002/bies.202300037","title":"Suicide gene‐enabled cell therapy: A novel approach to scalable human pluripotent stem cell quality control","year":2023,"lang":"en","type":"review","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Cumming School of Medicine, University of Calgary","keywords":"Induced pluripotent stem cell; Regenerative medicine; Cell therapy; Scalability; Cell; Bioreactor; Computer science; Biotechnology; Biochemical engineering; Stem cell; Biology; Engineering; Gene; Embryonic stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002023644,0.001096187,0.002232723,0.0003623487,0.0003362485,0.0002025799,0.001780262,0.00113923,0.0000268773],"category_scores_gemma":[0.00004648156,0.0009092058,0.001122243,0.0006943961,0.0001385208,0.000007096514,0.0007919731,0.0006033327,0.0005983347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016713,"about_ca_system_score_gemma":0.0006622278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002743927,"about_ca_topic_score_gemma":0.00002052232,"domain_scores_codex":[0.9934287,0.0007794714,0.00137367,0.002057137,0.0009063459,0.001454685],"domain_scores_gemma":[0.9963427,0.0001411497,0.0005843674,0.002052935,0.00027398,0.0006049038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003588462,0.004033694,0.0000486857,0.05455871,0.001973434,0.00007717124,0.0001185444,0.0003133712,0.8169016,0.0002091904,0.02988966,0.0915171],"study_design_scores_gemma":[0.002237875,0.0003793444,0.00001202199,0.0009439304,0.000247324,0.00001634149,0.00004788353,0.00002863426,0.01798383,0.000007461485,0.9767197,0.001375621],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005189923,0.9814428,0.002590186,0.00004400269,0.0002779693,0.004438217,0.001047764,0.0001288096,0.009511252],"genre_scores_gemma":[0.0007607001,0.9571295,0.0005535579,0.0002044584,0.0006390999,0.001248534,0.001832328,0.0003705372,0.0372613],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9468301,"threshold_uncertainty_score":0.9993359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1196396369233707,"score_gpt":0.3584405206948516,"score_spread":0.2388008837714809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}