{"id":"W4385851459","doi":"10.1002/bies.202300037","title":"Suicide gene‐enabled cell therapy: A novel approach to scalable human pluripotent stem cell quality control","year":2023,"lang":"en","type":"review","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Cumming School of Medicine, University of Calgary","keywords":"Induced pluripotent stem cell; Regenerative medicine; Cell therapy; Scalability; Cell; Bioreactor; Computer science; Biotechnology; Biochemical engineering; Stem cell; Biology; Engineering; Gene; Embryonic stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008537845,0.0009352815,0.0009513235,0.001883244,0.0002328768,0.001071407,0.001080509,0.00122398,0.002090999],"category_scores_gemma":[0.0004655154,0.0004265995,0.000657868,0.001635799,0.0007255489,0.001427704,0.0008021444,0.002661628,0.001440528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001039236,"about_ca_system_score_gemma":0.0008786299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008580851,"about_ca_topic_score_gemma":0.0009762871,"domain_scores_codex":[0.9996632,0.00004321906,0.00002810128,0.00005244575,0.0001823615,0.00003064781],"domain_scores_gemma":[0.999814,0.00008298871,0.00002898222,0.000008817113,0.00005075476,0.00001455797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00005497744,0.0001083921,0.0001294914,0.01650393,0.00009716472,0.0004105171,0.0001230338,0.001433029,0.04048676,0.0326497,0.01778305,0.8902199],"study_design_scores_gemma":[0.00001909754,0.0001687191,0.000275135,0.00113711,0.00006778372,0.001057873,0.0000374925,0.0004128537,0.0130784,0.003711908,0.9800005,0.00003319312],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005454786,0.9903702,0.00459271,0.0004374846,0.0003898007,0.00002995807,0.00004197544,0.0000378013,0.003554558],"genre_scores_gemma":[0.003345657,0.9917722,0.002588202,0.0003235093,0.0001206625,0.00004035754,0.00006901192,0.000007043815,0.001733288],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002090999,"threshold_uncertainty_score":0.007540226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1196396369233707,"score_gpt":0.3584405206948516,"score_spread":0.2388008837714809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}