{"id":"W4385851741","doi":"10.1158/2159-8290.cd-23-0131","title":"Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency; University of British Columbia Hospital","funders":"National Human Genome Research Institute; Helse Sør-Øst RHF; National Institutes of Health; Fondation Gustave Roussy; Daegu Gyeongbuk Institute of Science and Technology; Norges Forskningsråd; Universitetet i Oslo; National Research Foundation of Korea; Sontag Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; A. Alfred Taubman Medical Research Institute; Hyundai Hope On Wheels; Pediatric Brain Tumor Foundation; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Prayers from Maria; National Cancer Institute; Making Headway Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Downregulation and upregulation; Epigenetics; Pathognomonic; Medicine; Glioma; Mutant; Cancer research; Pharmacology; Internal medicine; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599924,0.000173168,0.0006685242,0.0001978185,0.00001707112,0.0000101876,0.00006635194,0.0001000056,0.00004279572],"category_scores_gemma":[0.0001075279,0.0001272636,0.0001575658,0.0005858769,0.0001635498,0.00007989394,0.00005695163,0.0001134495,0.000005703256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005964815,"about_ca_system_score_gemma":0.0001391765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005226214,"about_ca_topic_score_gemma":0.0001358571,"domain_scores_codex":[0.998554,0.00006495964,0.0006220717,0.0003363732,0.0002109114,0.0002117199],"domain_scores_gemma":[0.999164,0.0001883825,0.0001847322,0.0002932938,0.00005948332,0.0001101088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003937163,0.001707162,0.8551336,0.0001375987,0.0002561962,0.00006676142,0.0004279343,0.00002766394,0.1202499,0.00007691306,0.0004898701,0.02103264],"study_design_scores_gemma":[0.006619222,0.0003567133,0.8977762,0.0004323545,0.0003054073,0.000003269263,0.0001310221,0.0004983774,0.09297199,0.00006227269,0.0007259184,0.0001172482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899604,0.008343601,0.00001378735,0.0003937239,0.000163008,0.0004283588,0.0006542508,0.00002056502,0.00002225304],"genre_scores_gemma":[0.9851283,0.01439962,0.00003052163,0.00008090092,0.00005106683,0.00006156365,0.0001549417,0.0000232547,0.00006987713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0426426,"threshold_uncertainty_score":0.518966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591447923270457,"score_gpt":0.3379691257988777,"score_spread":0.3020546465661731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}