{"id":"W4385851741","doi":"10.1158/2159-8290.cd-23-0131","title":"Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia; BC Cancer Agency; University of British Columbia Hospital","funders":"National Human Genome Research Institute; Helse Sør-Øst RHF; National Institutes of Health; Fondation Gustave Roussy; Daegu Gyeongbuk Institute of Science and Technology; Norges Forskningsråd; Universitetet i Oslo; National Research Foundation of Korea; Sontag Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; A. Alfred Taubman Medical Research Institute; Hyundai Hope On Wheels; Pediatric Brain Tumor Foundation; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Prayers from Maria; National Cancer Institute; Making Headway Foundation; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Downregulation and upregulation; Epigenetics; Pathognomonic; Medicine; Glioma; Mutant; Cancer research; Pharmacology; Internal medicine; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682368,0.0002299119,0.0003270392,0.0001510644,0.0001292806,0.0002951808,0.0001653175,0.0001805303,0.0008305423],"category_scores_gemma":[0.0001646724,0.000063574,0.0001868677,0.0001741934,0.0002664202,0.0001304341,0.0001803818,0.0003304289,0.0001216218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000388109,"about_ca_system_score_gemma":0.0003270906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004134659,"about_ca_topic_score_gemma":0.001614182,"domain_scores_codex":[0.9999137,0.00001443053,0.000008648733,0.00001379481,0.00002615634,0.00002321327],"domain_scores_gemma":[0.9999002,0.00001326386,0.00003275328,0.00001065531,0.00001072854,0.00003234069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01345997,0.002338984,0.0499444,0.0003756295,0.0002207437,0.0009243066,0.0001022392,0.001905335,0.8110344,0.000282432,0.001019535,0.1183921],"study_design_scores_gemma":[0.001931377,0.06584553,0.2942927,0.00004930311,0.0003965689,0.006575696,0.0003460625,0.002499123,0.6193795,0.0003386042,0.00830575,0.00003973183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983871,0.0004701462,0.0001499465,0.00004240131,0.000005134216,0.00002705972,0.0001020167,0.00001909499,0.0007971906],"genre_scores_gemma":[0.999145,0.000197818,0.0001111097,0.00002325631,0.000003211997,0.00001188429,0.0002793044,0.000004510235,0.0002237992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008305423,"threshold_uncertainty_score":0.002815962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591447923270457,"score_gpt":0.3379691257988777,"score_spread":0.3020546465661731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}