{"id":"W4385852479","doi":"10.21203/rs.3.rs-3182457/v1","title":"Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Calgary; University of Guelph; University of Ottawa","funders":"National Institute on Aging; University of California, San Francisco; University of California, San Diego; Canadian Institutes of Health Research; Parkinson Canada; Parkinson's Foundation; Ottawa Hospital Research Institute; University of Ottawa; Michael J. Fox Foundation for Parkinson's Research","keywords":"Reduction (mathematics); Computer science; Biology; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338797,0.0004316128,0.0002933119,0.0002952773,0.0001611699,0.0002822436,0.0003382902,0.0003089454,0.001442345],"category_scores_gemma":[0.0001071789,0.0001318787,0.000262831,0.0001529346,0.0002831603,0.0001682494,0.0001470976,0.0005865205,0.0003147271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000334525,"about_ca_system_score_gemma":0.0003323155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008806663,"about_ca_topic_score_gemma":0.001604603,"domain_scores_codex":[0.999889,0.00001000134,0.00001527338,0.00002520368,0.00002860951,0.0000318515],"domain_scores_gemma":[0.999898,0.00001475541,0.00002977249,0.00001094603,0.00001505766,0.00003154803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003130575,0.000171821,0.0001626584,0.00006325361,0.0000146858,0.00003600567,0.000007427293,0.00019342,0.9967377,0.0001816973,0.00008619621,0.00203198],"study_design_scores_gemma":[0.00005978816,0.0009597056,0.001297415,0.000006020403,0.00002178125,0.00009911528,0.00001528546,0.0008189682,0.994908,0.00005529264,0.001754272,0.000004285414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923274,0.001438671,0.002871274,0.0001524267,0.00007989536,0.000117954,0.0008540485,0.0001673764,0.001991051],"genre_scores_gemma":[0.9939168,0.0008439739,0.002166902,0.0000536454,0.0000117508,0.00007033152,0.0005271012,0.00002882851,0.002380689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442345,"threshold_uncertainty_score":0.004825115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1660183835969188,"score_gpt":0.414568288339714,"score_spread":0.2485499047427952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}