{"id":"W4385856750","doi":"10.1097/01.hs9.0000972776.91875.6f","title":"P1473: CLINICALLY RELEVANT HEMOGLOBIN RESPONSE IN ADULTS WITH PYRUVATE KINASE DEFICIENCY TREATED WITH MITAPIVAT – A SUB-ANALYSIS OF THE ACTIVATE TRIAL","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Anemia; Hemoglobin; Hemolysis; Clinical endpoint; Pyruvate kinase; Placebo; Pyruvate kinase deficiency; Internal medicine; Randomized controlled trial; Gastroenterology; Clinical trial; Pharmacology; Glycolysis; Pathology; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005774867,0.0002233267,0.0003736581,0.0001010725,0.00006425224,0.00001665437,0.0003745588,0.0002157887,0.00002432894],"category_scores_gemma":[0.0004448819,0.0001293546,0.0002446799,0.002256873,0.000262027,0.000004167533,0.0002000075,0.0002293596,0.000007636143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002604808,"about_ca_system_score_gemma":0.0002232444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009315971,"about_ca_topic_score_gemma":0.0002715307,"domain_scores_codex":[0.9978244,0.0003150547,0.0004179518,0.00059435,0.000413008,0.0004352207],"domain_scores_gemma":[0.9986998,0.00009905511,0.0001632695,0.0007755779,0.0001501239,0.0001121937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1619959,0.0002854952,0.009434856,0.00004702431,0.0003245469,0.00006889337,0.00006094711,0.0001992861,0.8267913,0.00001173515,0.0002304133,0.0005496542],"study_design_scores_gemma":[0.0188871,0.003084818,0.02162488,0.0001729571,0.0002701146,0.000005565217,0.0002571966,0.0002529543,0.954566,0.00001506606,0.0005339521,0.0003294206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984622,0.0001447023,0.00003837329,0.0003884746,0.00001685014,0.0006068788,0.00003588894,0.00002062554,0.0002860151],"genre_scores_gemma":[0.9987984,0.00009034362,0.0001111991,0.00008318964,0.00002179039,0.00008018268,0.00009210671,0.00003155915,0.0006911858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1431088,"threshold_uncertainty_score":0.5274929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235779640167114,"score_gpt":0.2720941681591238,"score_spread":0.2597363717574527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}