{"id":"W4385856750","doi":"10.1097/01.hs9.0000972776.91875.6f","title":"P1473: CLINICALLY RELEVANT HEMOGLOBIN RESPONSE IN ADULTS WITH PYRUVATE KINASE DEFICIENCY TREATED WITH MITAPIVAT – A SUB-ANALYSIS OF THE ACTIVATE TRIAL","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Anemia; Hemoglobin; Hemolysis; Clinical endpoint; Pyruvate kinase; Placebo; Pyruvate kinase deficiency; Internal medicine; Randomized controlled trial; Gastroenterology; Clinical trial; Pharmacology; Glycolysis; Pathology; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001736889,0.0006835326,0.001445143,0.0001896823,0.0001584509,0.0009160147,0.0003715979,0.0007710694,0.003204335],"category_scores_gemma":[0.002076651,0.0002055209,0.002416412,0.0003342295,0.0003737154,0.0005803619,0.000332389,0.001666846,0.0004281887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004892724,"about_ca_system_score_gemma":0.000518575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004442417,"about_ca_topic_score_gemma":0.001187074,"domain_scores_codex":[0.9993642,0.0003857026,0.00005027265,0.00007676608,0.00004606029,0.00007700343],"domain_scores_gemma":[0.9991155,0.0003180425,0.0002711457,0.00007060695,0.00007391322,0.0001506353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9119245,0.002109243,0.0126328,0.002481921,0.00751705,0.0001401958,0.0001182515,0.0007434067,0.003826614,0.0004116875,0.004276711,0.05381767],"study_design_scores_gemma":[0.8128154,0.1015938,0.06419786,0.000400578,0.01173203,0.0004820989,0.0001525519,0.001498974,0.001318661,0.0009486171,0.00480739,0.00005196226],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802935,0.01112477,0.0004239427,0.0009332074,0.0002097696,0.001336425,0.002240888,0.00005720624,0.003380229],"genre_scores_gemma":[0.9910275,0.002921976,0.00047612,0.0009247108,0.0003374569,0.001126525,0.002139855,0.00001337988,0.001032509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003204335,"threshold_uncertainty_score":0.0107196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235779640167114,"score_gpt":0.2720941681591238,"score_spread":0.2597363717574527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}