{"id":"W4385857514","doi":"10.21203/rs.3.rs-3259040/v1","title":"The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institutes of Health; Northwestern University","keywords":"Human immunodeficiency virus (HIV); Genetically modified organism; Replication (statistics); Biology; Virology; Genetically engineered; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006565202,0.0003359721,0.001099408,0.0008717697,0.000341839,0.001810279,0.0005744707,0.0006293206,0.006355143],"category_scores_gemma":[0.00123332,0.0003399595,0.0003754134,0.0003411048,0.0004737032,0.001633778,0.0007222449,0.001340082,0.004293619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000331325,"about_ca_system_score_gemma":0.0004452354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003287619,"about_ca_topic_score_gemma":0.0001867728,"domain_scores_codex":[0.9996504,0.00004242848,0.00002374373,0.00009712996,0.0001213323,0.00006504711],"domain_scores_gemma":[0.9992685,0.000174428,0.000153188,0.0001673413,0.0001044357,0.0001320411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003174536,0.00008516481,0.007595071,0.0002896395,0.00003493497,0.0005510497,0.000325728,0.000350097,0.9423211,0.005183264,0.001138653,0.04180782],"study_design_scores_gemma":[0.0001791191,0.002199031,0.1062762,0.0002839781,0.0002331744,0.01287496,0.0007190146,0.009967971,0.7223623,0.01572399,0.1290358,0.0001445023],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8998184,0.02125736,0.05696585,0.001149164,0.000410417,0.0002671331,0.003302524,0.000752381,0.0160768],"genre_scores_gemma":[0.9439501,0.006566965,0.01689457,0.0005137499,0.000680663,0.0002516984,0.003404246,0.0003952806,0.02734265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006355143,"threshold_uncertainty_score":0.02126002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05081184277987627,"score_gpt":0.327934979979688,"score_spread":0.2771231371998117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}