{"id":"W4385872109","doi":"10.1101/2023.08.16.553481","title":"Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Japan Heart Foundation; Institute of Genetics; Korea Advanced Institute of Science and Technology; University of Melbourne; Uppsala Universitet; Deutsche Forschungsgemeinschaft; Japan Foundation for Applied Enzymology","keywords":"Zebrafish; Biology; Cell biology; Receptor tyrosine kinase; Lymphangiogenesis; Signal transduction; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000771553,0.0003709907,0.0001810552,0.000283895,0.0003107224,0.0001901684,0.0002176324,0.0003030245,0.002822742],"category_scores_gemma":[0.00006914972,0.0002685683,0.0003339591,0.00009545732,0.0002290926,0.0001882894,0.0003054214,0.0006726191,0.0007888178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007351867,"about_ca_system_score_gemma":0.0003292927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003878142,"about_ca_topic_score_gemma":0.005623254,"domain_scores_codex":[0.9998835,0.000007321769,0.00000763658,0.00003131082,0.00004147095,0.00002872319],"domain_scores_gemma":[0.9999062,0.00000836578,0.00003479621,0.000005046527,0.00001124526,0.00003440549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001700501,0.000002405105,0.0001028761,0.00001367111,0.000001222872,0.00003585526,0.000005366861,0.00003794055,0.9993755,0.00006964253,0.0000376253,0.00030096],"study_design_scores_gemma":[0.00002098278,0.00007644004,0.01182273,0.00001281266,0.00002075644,0.0002464667,0.00003867916,0.001748359,0.9817831,0.00007683537,0.004142213,0.00001066284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860248,0.001482095,0.005896701,0.0002251179,0.00005633017,0.00004047412,0.001303379,0.0001989252,0.004772163],"genre_scores_gemma":[0.9800553,0.0009468094,0.004395481,0.0001351476,0.00001176676,0.00007066737,0.00110805,0.000105067,0.01317168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003878142,"threshold_uncertainty_score":0.009442985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0364077562557975,"score_gpt":0.2612045307005145,"score_spread":0.224796774444717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}