{"id":"W4385873492","doi":"10.3390/cancers15164127","title":"Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Laurentian University; University of Ottawa; Université du Québec à Montréal; Ottawa Hospital; Health Sciences North","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Cancer immunotherapy; DNA damage; Immunotherapy; Cancer; Tumor microenvironment; Sting; Medicine; Cancer research; Immune system; Immunology; Biology; DNA; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004355075,0.0007110368,0.000878645,0.001368662,0.0002286505,0.0008961654,0.0005113688,0.001086949,0.001574405],"category_scores_gemma":[0.0004043375,0.0002203005,0.000416881,0.001377002,0.0004910841,0.001490127,0.0003905112,0.001662872,0.0006919437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005508541,"about_ca_system_score_gemma":0.0007834619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000474116,"about_ca_topic_score_gemma":0.0008216149,"domain_scores_codex":[0.9998826,0.00002688223,0.0000175917,0.00002445697,0.00003469091,0.00001377122],"domain_scores_gemma":[0.999757,0.0001401515,0.00003580542,0.000005929272,0.00004020179,0.00002104874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001456396,0.0001471572,0.0003117789,0.02951172,0.0000908576,0.0004972491,0.000256719,0.0007944934,0.01020474,0.01354451,0.03957163,0.9049235],"study_design_scores_gemma":[0.00001062029,0.0002292654,0.0007262789,0.002832756,0.00008379013,0.001589151,0.0001307089,0.0001714183,0.001277226,0.003244349,0.9896808,0.00002363299],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002341022,0.9982963,0.0001894395,0.0003584865,0.0002865336,0.000003322884,0.000007847483,0.000004658783,0.0006193262],"genre_scores_gemma":[0.0008418432,0.99793,0.0001884438,0.0002816929,0.0004084455,0.000006626754,0.0000132152,0.000001137249,0.0003285052],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001574405,"threshold_uncertainty_score":0.005266905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05964593280984219,"score_gpt":0.3487197174867851,"score_spread":0.2890737846769429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}