{"id":"W4385877387","doi":"10.3390/cancers15164119","title":"Where to Draw the LINE—Are Retrotransposable Elements Here to Stay?","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canadian Institutes of Health Research; Government of Ontario; Cancer Research Society","keywords":"DNA methylation; Methylation; Biology; Transposable element; Gene silencing; Somatic cell; Colorectal cancer; Intestinal epithelium; Epithelium; Retrotransposon; Cancer research; Cell biology; DNA; Computational biology; Genetics; Cancer; Gene expression; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001675692,0.0004342951,0.0009455329,0.0005690332,0.001618354,0.004393511,0.0009605007,0.003121694,0.006665334],"category_scores_gemma":[0.004335563,0.0003923229,0.0004538186,0.0005991731,0.003342008,0.01001812,0.001413512,0.005669284,0.004707941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120309,"about_ca_system_score_gemma":0.001385584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356923,"about_ca_topic_score_gemma":0.001861928,"domain_scores_codex":[0.9991553,0.000196615,0.00006957992,0.000248126,0.0001943515,0.0001360692],"domain_scores_gemma":[0.9979867,0.0005155432,0.000398293,0.0001696302,0.0005098025,0.0004200594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008852748,0.0001838115,0.02512233,0.002623176,0.0003979609,0.004590146,0.006062988,0.000537511,0.1667442,0.08318663,0.1098006,0.5998654],"study_design_scores_gemma":[0.00004956994,0.0003387439,0.007367373,0.0009174923,0.0001578362,0.004671724,0.01103134,0.0004141313,0.03689643,0.09583738,0.8420986,0.0002194376],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.07674681,0.3389098,0.04634252,0.4870548,0.02434634,0.00007777577,0.0008343195,0.0009514248,0.02473619],"genre_scores_gemma":[0.5148301,0.2517174,0.0334576,0.1233803,0.01061823,0.00009987019,0.001069848,0.0008998949,0.0639268],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006665334,"threshold_uncertainty_score":0.02229774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772252311646371,"score_gpt":0.2923649460125068,"score_spread":0.2746424228960431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}