{"id":"W4385877566","doi":"10.1038/s41467-023-40682-3","title":"Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Victoria; National Research Council Canada; University of Ottawa; Ottawa Hospital","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; University of Ottawa","keywords":"Astrocyte; HMGB1; Biology; Cell biology; Neuroscience; Aquaporin 4; Blood–brain barrier; Morphogenesis; Anatomy; Central nervous system; Immunology; Inflammation; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000109873,0.0001717522,0.0001750218,0.0003548767,0.000156411,0.0002387729,0.0001432706,0.0001921705,0.0005738004],"category_scores_gemma":[0.000119297,0.0001357559,0.0001631498,0.0001157597,0.0003060936,0.0001813133,0.0002150872,0.0003480455,0.0002041093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000253524,"about_ca_system_score_gemma":0.0002664807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185763,"about_ca_topic_score_gemma":0.002524479,"domain_scores_codex":[0.9998894,0.00001389601,0.000007443883,0.00002412892,0.00003128632,0.00003394556],"domain_scores_gemma":[0.9998459,0.00001046022,0.00005261525,0.00001090543,0.00001824101,0.0000618988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001372808,0.00001032628,0.001060593,0.00001758641,0.000003017541,0.0000680154,0.00003929628,0.00002096054,0.9972107,0.0001683187,0.00002818405,0.001235799],"study_design_scores_gemma":[0.00001178541,0.0001748961,0.07223171,0.00001263426,0.00002115868,0.0002620136,0.0001361148,0.0004305097,0.9247316,0.0001892467,0.001792316,0.000006073678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955494,0.001614253,0.001638155,0.00006000367,0.00001213782,0.000007810128,0.0001668586,0.00007288485,0.0008785829],"genre_scores_gemma":[0.9952851,0.001118632,0.001217452,0.00002910322,0.000007099713,0.00002356873,0.0001811433,0.00002457205,0.002113342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185763,"threshold_uncertainty_score":0.002357721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02672655571508966,"score_gpt":0.2807541018726175,"score_spread":0.2540275461575279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}