{"id":"W4385889336","doi":"10.17615/9cy6-py31","title":"African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer","year":2023,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ipsen; Canadian Institutes of Health Research; Cancer Council Victoria; European Society for Medical Oncology; University of California, San Diego; Manchester Biomedical Research Centre; National Institute for Health and Care Research; Norges Forskningsråd; Cancer Research UK; Génome Québec; Prostate Cancer Foundation; Prostate Cancer Foundation of Australia; Ovarian Cancer Research Fund; American Society of Clinical Oncology; Royal Marsden NHS Foundation Trust; National Cancer Research Institute; University of Rochester; H. Lundbeck A/S; Varian Medical Systems; National Institutes of Health; McGill University; National Health and Medical Research Council; Cancer Research Institute; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Prostate cancer; Cancer; Medicine; Oncology; Prostate; Hazard ratio; Hazard; Internal medicine; Biology; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002412769,0.00016847,0.0008950272,0.0003662518,0.0001281524,0.00004892878,0.0002661015,0.00009246141,0.0004795537],"category_scores_gemma":[0.0005844265,0.0001976024,0.0001858188,0.0003948294,0.0001713623,0.0004223314,0.0001371325,0.00006003487,0.0001654206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002190487,"about_ca_system_score_gemma":0.0001805103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006119556,"about_ca_topic_score_gemma":0.0002886209,"domain_scores_codex":[0.9964132,0.00004778732,0.002633315,0.0004242229,0.00009328088,0.0003881466],"domain_scores_gemma":[0.9967512,0.0009333995,0.001716797,0.0004404091,0.00005553923,0.0001026143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001467285,0.0001066211,0.4041559,0.001807446,0.0002143285,0.000001039601,0.009409678,0.0001730476,0.0001164737,0.4065948,0.1763712,0.0009028272],"study_design_scores_gemma":[0.003586455,0.0008315726,0.2202843,0.0004926664,0.00003989693,7.346925e-7,0.004849783,0.001197756,0.01004904,0.337156,0.4205071,0.001004737],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674075,0.007400879,0.0002101932,0.01781272,0.0007103207,0.00169679,0.003819957,0.00008511338,0.0008565487],"genre_scores_gemma":[0.9853221,0.001206345,0.003596206,0.001656272,0.0003134256,0.002285515,0.0002205913,0.00008177244,0.005317843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2441359,"threshold_uncertainty_score":0.8057991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3253168470852429,"score_gpt":0.3786861288387336,"score_spread":0.0533692817534907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}