{"id":"W4385889336","doi":"10.17615/9cy6-py31","title":"African-specific improvement of a polygenic hazard score for age at diagnosis of prostate cancer","year":2023,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ipsen; Canadian Institutes of Health Research; Cancer Council Victoria; European Society for Medical Oncology; University of California, San Diego; Manchester Biomedical Research Centre; National Institute for Health and Care Research; Norges Forskningsråd; Cancer Research UK; Génome Québec; Prostate Cancer Foundation; Prostate Cancer Foundation of Australia; Ovarian Cancer Research Fund; American Society of Clinical Oncology; Royal Marsden NHS Foundation Trust; National Cancer Research Institute; University of Rochester; H. Lundbeck A/S; Varian Medical Systems; National Institutes of Health; McGill University; National Health and Medical Research Council; Cancer Research Institute; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Prostate cancer; Cancer; Medicine; Oncology; Prostate; Hazard ratio; Hazard; Internal medicine; Biology; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01042071,0.0009814641,0.0008680716,0.0006370473,0.0003908035,0.0008754189,0.0009334743,0.0006362176,0.003454948],"category_scores_gemma":[0.01161378,0.000310777,0.002585091,0.0005637903,0.0003837969,0.0005539897,0.001134728,0.001072447,0.000489591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000391243,"about_ca_system_score_gemma":0.001210144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005637352,"about_ca_topic_score_gemma":0.004536035,"domain_scores_codex":[0.9972336,0.002086035,0.00009542894,0.0003318008,0.0001053572,0.0001478684],"domain_scores_gemma":[0.9945046,0.003970362,0.0004517854,0.0005419037,0.0003318089,0.0001994127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00355001,0.0003673563,0.4849564,0.0002016918,0.004105833,0.0005862566,0.000328942,0.3953918,0.005355309,0.00410118,0.002614544,0.09844062],"study_design_scores_gemma":[0.0001915519,0.0005868217,0.1032266,0.00006241507,0.000992563,0.0004606475,0.00007541737,0.8862947,0.001728186,0.004459711,0.001853072,0.0000684366],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9002616,0.001211859,0.09398451,0.001076918,0.00008826198,0.00007023175,0.001099498,0.0005070933,0.001700088],"genre_scores_gemma":[0.986499,0.0001809217,0.0115726,0.0001225039,0.00003609183,0.00003807693,0.000721687,0.00004792974,0.0007812236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01042071,"threshold_uncertainty_score":0.05511063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3253168470852429,"score_gpt":0.3786861288387336,"score_spread":0.0533692817534907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}