{"id":"W4385894466","doi":"10.1039/d3py00781b","title":"Bottlebrush polymer with dual functionality for osteoarthritis treatment: curcumin delivery and lubrication properties","year":2023,"lang":"en","type":"article","venue":"Polymer Chemistry","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Narodowe Centrum Nauki; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Curcumin; Osteoarthritis; Biocompatible material; Dual (grammatical number); Polymer; Lubrication; Materials science; Dual role; Biomedical engineering; Chemistry; Nanotechnology; Pharmacology; Medicine; Combinatorial chemistry; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005286296,0.0001782351,0.0001294407,0.00002033796,0.0001508229,0.0000268373,0.00007703931,0.0001362939,0.00004003296],"category_scores_gemma":[0.00001969024,0.0001501129,0.00005909982,0.0001504502,0.0002411766,0.000006396371,0.0000589534,0.00004211748,0.00001478636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002181056,"about_ca_system_score_gemma":0.000100143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005196001,"about_ca_topic_score_gemma":0.000007289554,"domain_scores_codex":[0.9989995,0.00001072028,0.0001660631,0.0004437427,0.0001296602,0.0002502782],"domain_scores_gemma":[0.9994267,0.00002054312,0.00006405171,0.0002994511,0.00006165018,0.0001276432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001259155,0.00006965103,0.001405539,0.00004980453,0.00006491947,0.000001129823,0.0000330833,3.964699e-7,0.9858559,0.00002695297,0.001392363,0.01097435],"study_design_scores_gemma":[0.0009466223,0.0001509396,0.0009335178,0.0000138532,0.00004706494,0.00003787944,0.00008274366,0.00002644267,0.9634939,0.00001478508,0.03405404,0.0001981996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916837,0.005276317,0.0003492822,0.001516842,0.00003681885,0.0002900196,0.0002900918,0.00006793764,0.0004890225],"genre_scores_gemma":[0.9877294,0.0001670855,0.0000622446,0.0001224873,0.0003722138,0.0006553591,0.001416434,0.00003055662,0.009444169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03266168,"threshold_uncertainty_score":0.6121428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536357155479453,"score_gpt":0.229307047738847,"score_spread":0.2139434761840525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}