{"id":"W4385897439","doi":"10.1007/s10815-023-02913-w","title":"PGT-A: Houston, we have a problem","year":2023,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Blastocyst; Loss of heterozygosity; Aneuploidy; Biology; Genetic testing; Live birth; Reproductive medicine; Preimplantation genetic diagnosis; Abortion; Genetics; Human genetics; Embryo transfer; Andrology; Inner cell mass; Embryo; Gynecology; Allele; Pregnancy; Medicine; Gene; Embryogenesis; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004315755,0.0000838225,0.0002017422,0.0001856985,0.00006536444,0.00002309428,0.0000401651,0.0000756907,0.00001038097],"category_scores_gemma":[0.0004211284,0.00006446414,0.00007252382,0.0002576585,0.00005813461,0.00003871224,0.00003199446,0.0002271297,0.00001060326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002238572,"about_ca_system_score_gemma":0.00007221704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000330505,"about_ca_topic_score_gemma":0.000001741848,"domain_scores_codex":[0.9990698,0.00003128253,0.000338564,0.0001665245,0.0002621464,0.0001317158],"domain_scores_gemma":[0.9991381,0.000040958,0.000201928,0.0001953438,0.0002700483,0.0001536279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0009692159,0.0004716463,0.08530985,0.0004570478,0.0004549379,0.0006922685,0.001340019,0.001385319,0.02543238,0.00007930312,0.1899358,0.6934722],"study_design_scores_gemma":[0.003549849,0.00253355,0.6763145,0.0006941599,0.0005862016,0.01018489,0.001360205,0.0008269473,0.01814972,0.0008017226,0.2847107,0.0002874737],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9612415,0.00841984,0.0007977241,0.02632489,0.0009352745,0.000235104,0.000005038656,0.0001052903,0.001935275],"genre_scores_gemma":[0.9765686,0.008348083,0.009551796,0.0001383601,0.001170736,0.000001901353,0.000006735837,0.00002178111,0.004191997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6931847,"threshold_uncertainty_score":0.2628771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03902229424619433,"score_gpt":0.3011449971087546,"score_spread":0.2621227028625603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}