{"id":"W4385897439","doi":"10.1007/s10815-023-02913-w","title":"PGT-A: Houston, we have a problem","year":2023,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Blastocyst; Loss of heterozygosity; Aneuploidy; Biology; Genetic testing; Live birth; Reproductive medicine; Preimplantation genetic diagnosis; Abortion; Genetics; Human genetics; Embryo transfer; Andrology; Inner cell mass; Embryo; Gynecology; Allele; Pregnancy; Medicine; Gene; Embryogenesis; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001600694,0.0004459747,0.0004126071,0.0006282341,0.004782935,0.003025564,0.001060254,0.005456852,0.07603922],"category_scores_gemma":[0.005727742,0.0002793747,0.0003868577,0.000657041,0.001747878,0.00218954,0.001893371,0.01043965,0.013908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00296861,"about_ca_system_score_gemma":0.00878215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01643435,"about_ca_topic_score_gemma":0.02413988,"domain_scores_codex":[0.9991012,0.0001503887,0.00005000212,0.0001661397,0.0002524451,0.000279864],"domain_scores_gemma":[0.9961903,0.0004111648,0.0001477723,0.0001675866,0.0006200354,0.002463171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005651964,0.00008366129,0.005220691,0.00005702554,0.000007779219,0.004680206,0.0003663886,0.00009364037,0.0002683585,0.009673804,0.9205561,0.05893585],"study_design_scores_gemma":[0.00005353387,0.00008209539,0.006237566,0.0002609695,0.0000166844,0.01086782,0.003187592,0.0002238223,0.0003247623,0.01249319,0.9662204,0.00003155864],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00697749,0.003055332,0.001091656,0.9139075,0.01300226,0.00003498242,0.0006578194,0.0003591793,0.06091379],"genre_scores_gemma":[0.1096291,0.007196872,0.009561701,0.5181504,0.01486178,0.0001214987,0.001418657,0.0007991584,0.3382608],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07603922,"threshold_uncertainty_score":0.2543765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03902229424619433,"score_gpt":0.3011449971087546,"score_spread":0.2621227028625603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}