{"id":"W4385897808","doi":"10.1242/dmm.049762","title":"An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity","year":2023,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; National University of Singapore; University of Toronto; Genentech; National Institutes of Health; Ontario Genomics; Canada Research Chairs; Canadian Institutes of Health Research; University of Southern California; Genome Canada; Institut National de la Santé et de la Recherche Médicale; University of Oxford","keywords":"Ubiquitin; Cell biology; Convergent extension; HEK 293 cells; Deubiquitinating enzyme; Transmembrane protein; Cell polarity; Biology; CDC42; Cell; Signal transduction; Receptor; Genetics; Gene; Embryogenesis; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000302152,0.0001419681,0.0001205514,0.00009730946,0.00008639696,0.00003294625,0.0001059508,0.0001197711,0.00000337426],"category_scores_gemma":[0.00003178872,0.0001546942,0.00005661064,0.00008399667,0.00001578883,0.00002616162,0.00004316685,0.00007524245,0.000004820811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001824687,"about_ca_system_score_gemma":0.0000581993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000372499,"about_ca_topic_score_gemma":0.00003243759,"domain_scores_codex":[0.9990333,0.00007086711,0.0001631241,0.0003807537,0.000118948,0.000233061],"domain_scores_gemma":[0.9995125,0.00001704499,0.00005631179,0.0001895544,0.00005232557,0.0001722834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006559846,0.000174056,0.001498569,0.0002077459,0.00002824866,0.000009876432,0.0004201327,0.003963104,0.9814909,0.006208543,0.0001014941,0.00524132],"study_design_scores_gemma":[0.00151244,0.0005225526,0.001262148,0.00004555214,0.0000569396,9.06152e-7,0.0006655683,0.1174203,0.8022025,0.07521974,0.0006601698,0.0004312519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9032323,0.00009404129,0.09527176,0.0001362729,0.00006580129,0.0004288896,0.0006644891,0.00004301736,0.00006340574],"genre_scores_gemma":[0.9948576,0.00005585256,0.001661642,0.0001722669,0.0001515882,0.000100251,0.002917005,0.00002777778,0.00005601078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1792885,"threshold_uncertainty_score":0.6308246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02975399940831075,"score_gpt":0.2885898553739956,"score_spread":0.2588358559656848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}