{"id":"W4385897808","doi":"10.1242/dmm.049762","title":"An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity","year":2023,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; National University of Singapore; University of Toronto; Genentech; National Institutes of Health; Ontario Genomics; Canada Research Chairs; Canadian Institutes of Health Research; University of Southern California; Genome Canada; Institut National de la Santé et de la Recherche Médicale; University of Oxford","keywords":"Ubiquitin; Cell biology; Convergent extension; HEK 293 cells; Deubiquitinating enzyme; Transmembrane protein; Cell polarity; Biology; CDC42; Cell; Signal transduction; Receptor; Genetics; Gene; Embryogenesis; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009551331,0.0002730185,0.0001514105,0.0002361097,0.0003464715,0.0003223037,0.0002301876,0.0003791279,0.00130198],"category_scores_gemma":[0.00007322844,0.0001445839,0.0001704144,0.0001251968,0.0002061497,0.0002358219,0.0002819644,0.0003610892,0.0004930099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004626289,"about_ca_system_score_gemma":0.0001425994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005275664,"about_ca_topic_score_gemma":0.001207079,"domain_scores_codex":[0.9999164,0.000008603231,0.000003203041,0.00002296828,0.00002836651,0.00002037571],"domain_scores_gemma":[0.9999527,0.000005314373,0.00001649479,0.000004295964,0.000003972425,0.00001735376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008576941,0.00001263412,0.0004633022,0.00002646109,0.000008238949,0.0002035834,0.00001282224,0.00006676844,0.9970829,0.0002975922,0.00005656855,0.001683312],"study_design_scores_gemma":[0.00001454393,0.0001018366,0.02376377,0.00001140787,0.00003243428,0.001380435,0.00007750082,0.003771155,0.9631861,0.0003610389,0.007291013,0.000008689399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913332,0.003475754,0.003008604,0.0001580457,0.00002367095,0.00000742044,0.0001678342,0.00004782038,0.001777685],"genre_scores_gemma":[0.9930725,0.001142181,0.001335767,0.0000858949,0.000007876918,0.00000690151,0.0002907996,0.00001149994,0.004046635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130198,"threshold_uncertainty_score":0.00435555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02975399940831075,"score_gpt":0.2885898553739956,"score_spread":0.2588358559656848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}