{"id":"W4385898740","doi":"10.1042/bcj20230119","title":"Development of an OTUD1 ubiquitin variant inhibitor","year":2023,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research; University of Guelph","funders":"University of Toronto; Canadian Institutes of Health Research; Cancer Research Society; Mitacs; Canadian Institute for Advanced Research","keywords":"Deubiquitinating enzyme; Ubiquitin; Ubiquitin ligase; Enzyme; Biochemistry; Biology; Chemistry; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670249,0.0005257649,0.0004806584,0.0002985875,0.0001653399,0.000462291,0.0007169689,0.0004096086,0.001040944],"category_scores_gemma":[0.0001087499,0.0001859679,0.0003680509,0.0002255524,0.0001501339,0.0002363656,0.0002335804,0.0007947186,0.0004051508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667426,"about_ca_system_score_gemma":0.0003144778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007850032,"about_ca_topic_score_gemma":0.00113691,"domain_scores_codex":[0.9998554,0.00001516357,0.00001068762,0.00003634958,0.00003747055,0.00004497212],"domain_scores_gemma":[0.9999487,0.000005163397,0.00001189266,0.000005537574,0.000009084526,0.00001953472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004802532,0.0003404299,0.0003271872,0.0001732558,0.00005205453,0.0001602206,0.00002404734,0.0008729628,0.9736558,0.0005823755,0.0004884615,0.02284302],"study_design_scores_gemma":[0.0002153035,0.002242815,0.001736554,0.00001577942,0.00008209494,0.00065241,0.00001899232,0.004329502,0.9683875,0.00008277426,0.02221735,0.00001893039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9308999,0.01976731,0.03608799,0.0005550311,0.0002537782,0.0007101204,0.001509567,0.0005866217,0.009629727],"genre_scores_gemma":[0.9698284,0.008492776,0.01058719,0.0002139426,0.00003129583,0.0002896228,0.002385975,0.00003170682,0.008139178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040944,"threshold_uncertainty_score":0.003482282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178245979383312,"score_gpt":0.2695484528104095,"score_spread":0.2477659930165763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}