{"id":"W4385898758","doi":"10.1177/14791641231197106","title":"Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with β-adrenergic receptor overactivation through restoring calcium handling and suppressing cardiomyocyte apoptosis","year":2023,"lang":"en","type":"article","venue":"Diabetes and Vascular Disease Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Natural Science Foundation of China","keywords":"Medicine; Ryanodine receptor; Ryanodine receptor 2; Endocrinology; Internal medicine; Apoptosis; Heart failure; Downregulation and upregulation; Calcium; Unfolded protein response; Endoplasmic reticulum; Calcium in biology; Cardiac function curve; Pharmacology; Chemistry; Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009478348,0.0001819426,0.0004168666,0.0003019401,0.000410144,0.00009314396,0.00002887757,0.0001012767,0.000002695678],"category_scores_gemma":[0.0002103642,0.000153761,0.00008950458,0.0006164751,0.0001726767,0.0002984157,0.0001146942,0.000407591,0.000002419221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007792295,"about_ca_system_score_gemma":0.0000995847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009932644,"about_ca_topic_score_gemma":0.000001434197,"domain_scores_codex":[0.9979335,0.000319936,0.0001779028,0.0005743097,0.0004320256,0.0005623362],"domain_scores_gemma":[0.9990571,0.0002688124,0.0000327071,0.0002633753,0.0001496965,0.0002283301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001400482,0.00007955232,0.3240537,0.001455386,0.0007894572,0.00007113087,0.00131563,0.003647049,0.6448985,0.0001517864,0.0002521825,0.02188517],"study_design_scores_gemma":[0.006330297,0.0007246524,0.8164018,0.003540271,0.0008358401,0.00001237128,0.002254922,0.04455195,0.1213825,0.001066128,0.001832215,0.001067043],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898124,0.00917821,0.00003642458,0.0003685462,0.00007621596,0.0004243692,0.00001054552,0.00005413803,0.00003917309],"genre_scores_gemma":[0.9928449,0.006427174,0.0001147036,0.00002179202,0.0002864845,0.00009965745,0.0001259855,0.00003583935,0.00004346022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5235159,"threshold_uncertainty_score":0.6270192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04482542627396434,"score_gpt":0.3197529060223647,"score_spread":0.2749274797484004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}