{"id":"W4385933292","doi":"10.1016/j.jcyt.2023.07.007","title":"Accessory-cell-free differentiation of hematopoietic stem and progenitor cells into mature red blood cells","year":2023,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Héma-Québec","funders":"Canadian Institutes of Health Research; Mitacs; Canada Foundation for Innovation","keywords":"Haematopoiesis; Progenitor cell; Enucleation; Cell biology; Erythropoiesis; Stem cell; Biology; Hemangioblast; Immunology; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008372648,0.0001519603,0.0003294152,0.0001361642,0.0000542264,0.00001222588,0.00009935828,0.0001747843,0.0002119354],"category_scores_gemma":[0.00000535781,0.00012409,0.00008268748,0.0002647981,0.00006192152,0.00004260667,0.00003757983,0.000135752,0.00004260976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001286102,"about_ca_system_score_gemma":0.00003290213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004625128,"about_ca_topic_score_gemma":0.000001969221,"domain_scores_codex":[0.9990981,0.00005912644,0.0002446072,0.0002575991,0.0001674245,0.0001731574],"domain_scores_gemma":[0.9992657,0.00005884577,0.0001285729,0.000387892,0.00007198934,0.00008701082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002629306,0.0001664144,0.001517528,0.0004801188,0.0000611213,0.00001122172,0.0009082739,0.000002147215,0.9905382,0.00003466479,0.005380133,0.0006372356],"study_design_scores_gemma":[0.003666059,0.0005048341,0.006344826,0.00007189836,0.00008671369,0.00001197934,0.00026265,0.00008257186,0.9866831,0.0003845562,0.001771025,0.0001297324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977953,0.0004777458,0.00006813763,0.0004348449,0.0004240884,0.0004269803,0.00001207596,0.0001282715,0.0002325782],"genre_scores_gemma":[0.9941449,0.001072707,0.0004836597,0.0003409,0.0002190476,0.00003714388,0.0000337438,0.0000435201,0.003624408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004827298,"threshold_uncertainty_score":0.5060245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472360091919548,"score_gpt":0.2498050573108157,"score_spread":0.2350814563916202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}