{"id":"W4385933547","doi":"10.1016/j.bcp.2023.115745","title":"Dynamic relationship between the aryl hydrocarbon receptor and long noncoding RNA balances cellular and toxicological responses","year":2023,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada); McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Ministry of Education – Kingdom of Saudi Arabi","keywords":"Aryl hydrocarbon receptor; Biology; Transcription factor; Xenobiotic; Aryl hydrocarbon receptor nuclear translocator; Mediator; Long non-coding RNA; Cell biology; Transcriptional regulation; Regulation of gene expression; Nuclear receptor; Signal transduction; Cell fate determination; Gene; RNA; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003384463,0.0002295507,0.0003562007,0.0003327273,0.0002883004,0.0009832081,0.0002436846,0.0004246765,0.001717196],"category_scores_gemma":[0.0004443056,0.0001512257,0.0003001879,0.0003484703,0.0004735637,0.0009899569,0.0006294613,0.0006078844,0.0006563294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004507463,"about_ca_system_score_gemma":0.0005298281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004506913,"about_ca_topic_score_gemma":0.0007532825,"domain_scores_codex":[0.9995721,0.00006431185,0.00002559476,0.0001613516,0.0001063022,0.00007038342],"domain_scores_gemma":[0.9996866,0.00005822728,0.00006864266,0.00002063853,0.0001097222,0.00005613768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001297518,0.00003732436,0.008843275,0.0006606747,0.00007966982,0.0004868105,0.000343789,0.0004810333,0.9055756,0.01023172,0.002094637,0.07103565],"study_design_scores_gemma":[0.00005093583,0.0009552687,0.2641026,0.0005470997,0.0005093469,0.003780381,0.002648377,0.00672956,0.3089554,0.02576188,0.3857334,0.0002257665],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6058962,0.2585207,0.07273536,0.008917408,0.001808551,0.0001356663,0.002271993,0.001423427,0.04829076],"genre_scores_gemma":[0.9077517,0.05760648,0.01387404,0.002555705,0.001068686,0.0001333294,0.001318768,0.0001547077,0.01553658],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001717196,"threshold_uncertainty_score":0.005744636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07124214274689132,"score_gpt":0.3926693782268392,"score_spread":0.3214272354799478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}