{"id":"W4385935099","doi":"10.2139/ssrn.4539214","title":"A Replica Plating Method for Efficient, High-Throughput Screening of Antibiotic Gene Clusters in Bacteria Uncovers a Holomycin-Like Cluster in the Clinical Isolate, Pantoea Agglomerans 20kb447973","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Microbial Metabolites in Food Biotechnology","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Regina","funders":"","keywords":"Pantoea agglomerans; Replica; Cluster (spacecraft); Bacteria; Microbiology; Throughput; Pantoea; Gene cluster; Antibiotics; Biology; Computer science; Genetics; Geography; Wireless; 16S ribosomal RNA; Computer network; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001015113,0.001227947,0.001191425,0.001817492,0.0005653972,0.0008233586,0.001582099,0.001031641,0.003529392],"category_scores_gemma":[0.00191751,0.0007099874,0.0008611619,0.001466099,0.0004683111,0.0003913913,0.0007728419,0.001322286,0.004907485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001941395,"about_ca_system_score_gemma":0.0003325647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008665242,"about_ca_topic_score_gemma":0.001127918,"domain_scores_codex":[0.9983703,0.0003409423,0.0001381155,0.0003915758,0.0006433495,0.0001156673],"domain_scores_gemma":[0.9983034,0.0007536756,0.0001321546,0.0004838271,0.0002317446,0.00009524804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000702906,0.00005950468,0.0005221331,0.00006902323,0.00001715651,0.00007972864,0.00005123856,0.00004941097,0.9889498,0.0000442765,0.0002993115,0.009788068],"study_design_scores_gemma":[0.00002524323,0.0006199818,0.006045323,0.00002349387,0.0000999193,0.000905497,0.0001082071,0.00167,0.9868791,0.0001078131,0.00348062,0.00003486357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4844047,0.005290614,0.485589,0.0009367298,0.0007299915,0.002143296,0.008144642,0.005405754,0.007355198],"genre_scores_gemma":[0.5144553,0.005316288,0.4437518,0.0003347246,0.000218527,0.00226875,0.0146709,0.00133165,0.017652],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003529392,"threshold_uncertainty_score":0.01180702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03892968324619452,"score_gpt":0.3541725344079765,"score_spread":0.315242851161782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}