{"id":"W4385948804","doi":"10.3390/biom13081257","title":"Senolytic Combination Treatment Is More Potent Than Single Drugs in Reducing Inflammatory and Senescence Burden in Cells from Painful Degenerating IVDs","year":2023,"lang":"en","type":"article","venue":"Biomolecules","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital; Shriners Hospitals for Children - Canada; McGill University","funders":"Canadian Institutes of Health Research; Arthritis Society; Gadfly Project; Louise and Alan Edwards Foundation; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Proinflammatory cytokine; Pharmacology; Medicine; Vanillin; In vitro; Inflammation; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473899,0.0004219804,0.0009159283,0.0005605005,0.0001918681,0.000349082,0.0002639078,0.0003331685,0.002123916],"category_scores_gemma":[0.0001261592,0.0001166651,0.0004864777,0.0002276282,0.000187383,0.0002521735,0.0002391705,0.0006612621,0.0002586039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139257,"about_ca_system_score_gemma":0.000232589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002512759,"about_ca_topic_score_gemma":0.000981285,"domain_scores_codex":[0.9998267,0.00002921108,0.00002336993,0.00003609757,0.00004249356,0.00004209987],"domain_scores_gemma":[0.9998926,0.00001473582,0.00002380935,0.00001288647,0.00001631221,0.00003965737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001653349,0.0005944649,0.0005401987,0.0004206883,0.00008200337,0.00009145206,0.0000308941,0.0001459352,0.9789132,0.00005966106,0.0001612524,0.01730679],"study_design_scores_gemma":[0.0003463039,0.01771034,0.01428256,0.00007236094,0.0003219707,0.0008448459,0.0001518039,0.0006495385,0.9567619,0.0000763208,0.008755061,0.00002701222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885577,0.00831596,0.00125165,0.000113465,0.00009646966,0.00008179314,0.0001999926,0.00007275117,0.001310222],"genre_scores_gemma":[0.9893801,0.005430385,0.002580616,0.00008625213,0.00005621967,0.0001252598,0.0003917046,0.00001485778,0.001934665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002123916,"threshold_uncertainty_score":0.007105231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128482178849948,"score_gpt":0.2737147756842639,"score_spread":0.2524299538957644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}