{"id":"W4385953972","doi":"10.1093/braincomms/fcad216","title":"Association of the fibronectin type III domain–containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Queen's University","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Biogen; Pfizer; Instituto Serrapilheira; Servier; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Eisai; Genentech; IXICO; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Northern California Institute for Research and Education; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"FNDC5; Endocrinology; Alzheimer's disease; Internal medicine; Allele; Biology; Single-nucleotide polymorphism; Medicine; Genetics; Disease; Gene; Genotype; Fibronectin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002597866,0.0005157593,0.0003423187,0.0005992639,0.0005353839,0.0003765296,0.0002015438,0.0005515763,0.001933638],"category_scores_gemma":[0.0005549013,0.0002091725,0.0004168305,0.0005579952,0.0002076953,0.0001096697,0.0002065339,0.0003286902,0.000156631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008414588,"about_ca_system_score_gemma":0.00008936945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003280428,"about_ca_topic_score_gemma":0.002528639,"domain_scores_codex":[0.9998395,0.00002959457,0.00002403868,0.0000599782,0.00002743264,0.00001934486],"domain_scores_gemma":[0.999673,0.00007251422,0.0001269659,0.00003615951,0.00002877696,0.00006267568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001753435,0.00009977919,0.9663594,0.00004437795,0.0005472704,0.002589788,0.0002889873,0.0001731456,0.02463781,0.0001124371,0.0002936488,0.003099951],"study_design_scores_gemma":[0.00002621219,0.0002424614,0.9971288,0.00000637629,0.0001060584,0.001301404,0.00009494997,0.0002827455,0.0005100021,0.00008673388,0.0002068383,0.000007466037],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994957,0.0001231688,0.00009524973,0.00001886109,0.000009116333,0.000003384079,0.0001254093,0.000002683903,0.0001262952],"genre_scores_gemma":[0.9995449,0.00004684111,0.0000844968,0.00002221983,0.00001319702,0.000003246042,0.0001124678,0.000001609045,0.000170957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003280428,"threshold_uncertainty_score":0.006522655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0311667803443095,"score_gpt":0.2892529351281599,"score_spread":0.2580861547838504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}