{"id":"W4385953972","doi":"10.1093/braincomms/fcad216","title":"Association of the fibronectin type III domain–containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Queen's University","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Biogen; Pfizer; Instituto Serrapilheira; Servier; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Eisai; Genentech; IXICO; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Northern California Institute for Research and Education; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"FNDC5; Endocrinology; Alzheimer's disease; Internal medicine; Allele; Biology; Single-nucleotide polymorphism; Medicine; Genetics; Disease; Gene; Genotype; Fibronectin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001135723,0.000194229,0.0004638713,0.0002738629,0.0003173603,0.00002657698,0.0006189098,0.000147305,0.00004964511],"category_scores_gemma":[0.001112358,0.0001556181,0.0001132038,0.001670493,0.0001619089,0.0001439302,0.0002793056,0.0005058412,0.00003764078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001528147,"about_ca_system_score_gemma":0.0002718913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007536687,"about_ca_topic_score_gemma":0.001693242,"domain_scores_codex":[0.9979298,0.0005141106,0.0005382052,0.0002551125,0.0003848029,0.0003780306],"domain_scores_gemma":[0.9968191,0.0006523118,0.000413294,0.001823717,0.000202237,0.00008932812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003121177,0.0005967972,0.003057751,0.00005847678,0.0003612275,0.00001015264,0.01396696,0.00002060115,0.9516826,0.01225865,0.007927977,0.009746664],"study_design_scores_gemma":[0.01414584,0.001241048,0.4745789,0.002162234,0.0007129816,0.00005131576,0.008066971,0.0003139021,0.072232,0.00674676,0.4187303,0.001017759],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9248692,0.001519621,0.00002130413,0.06790055,0.0001088751,0.001173265,0.00001272986,0.000143713,0.004250684],"genre_scores_gemma":[0.986715,0.00008626761,0.002154841,0.0007270757,0.0001042677,0.0001230218,0.00007016125,0.0000562205,0.009963192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8794506,"threshold_uncertainty_score":0.6345921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0311667803443095,"score_gpt":0.2892529351281599,"score_spread":0.2580861547838504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}