{"id":"W4385954285","doi":"10.1038/s41598-023-37710-z","title":"Distortion of Mendelian segregation across the Angus cattle genome uncovering regions affecting reproduction","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic and phenotypic traits in livestock","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada; Beef Cattle Research Council; Beef Farmers of Ontario; Alberta Beef Producers","keywords":"Biology; Genetics; Offspring; Allele; Single-nucleotide polymorphism; SNP; Genetic load; Mendelian inheritance; Genotype; Evolutionary biology; Pregnancy; Gene; Inbreeding; Population; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002458057,0.0004662937,0.0006995948,0.00197518,0.0003628964,0.0009105366,0.0004474939,0.0002912151,0.0018779],"category_scores_gemma":[0.003483529,0.0002510185,0.0007595185,0.002140042,0.0005151893,0.0002325424,0.0004369704,0.0003990023,0.0001673495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266248,"about_ca_system_score_gemma":0.0003257099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473617,"about_ca_topic_score_gemma":0.003159507,"domain_scores_codex":[0.9968699,0.00128269,0.0002701258,0.0009598191,0.0004556224,0.0001618886],"domain_scores_gemma":[0.9970037,0.001692516,0.0007579781,0.0002797064,0.0001334876,0.0001326792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002372343,0.0001123819,0.8336126,0.0002335461,0.002244381,0.001879588,0.0007949467,0.003303779,0.1029296,0.001013503,0.0003521857,0.05115115],"study_design_scores_gemma":[0.00003241197,0.0002034622,0.985402,0.00001886168,0.0004419205,0.001469585,0.0001903172,0.007383712,0.003494073,0.0005016215,0.0008387286,0.00002322663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921436,0.0007913622,0.005987052,0.00003456209,0.00001099424,0.00001156346,0.0004122478,0.00007702337,0.0005316695],"genre_scores_gemma":[0.9960275,0.0001819244,0.002985057,0.00002732511,0.00001076405,0.00001337305,0.000567815,0.00002302104,0.0001631737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002473617,"threshold_uncertainty_score":0.01299959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636516870371356,"score_gpt":0.266179022207336,"score_spread":0.2498138535036225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}