{"id":"W4385955318","doi":"10.3390/biomedicines11082282","title":"Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"King Saud University","keywords":"CYP2C9; Pharmacogenetics; Allele; Type 2 Diabetes Mellitus; Internal medicine; Population; Medicine; Allele frequency; Genotype; Biology; Diabetes mellitus; Pharmacology; Genetics; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003628131,0.0003683039,0.0004271386,0.0006720892,0.0007995315,0.0004859229,0.0002489006,0.0005149495,0.00137326],"category_scores_gemma":[0.0008579991,0.0004566666,0.0004470424,0.0009681383,0.0003269098,0.0003424715,0.0002548761,0.0005198001,0.0001627448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334591,"about_ca_system_score_gemma":0.0002400217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005758922,"about_ca_topic_score_gemma":0.00506399,"domain_scores_codex":[0.9996934,0.00006534786,0.00003264489,0.00009885082,0.00006308546,0.00004668149],"domain_scores_gemma":[0.9995065,0.00009451609,0.000197616,0.00003560659,0.00004707594,0.0001186451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001508471,0.00007062811,0.9978302,0.000009232287,0.00004098978,0.0005120388,0.0002120832,0.00001858291,0.0003655118,0.00001210793,0.00003916886,0.0007386197],"study_design_scores_gemma":[0.00001563431,0.0001915606,0.9979351,0.000004533183,0.00002823828,0.00126991,0.0002659072,0.0001320777,0.00005374836,0.0000172323,0.00008181364,0.000004274301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996768,0.00006785276,0.00003951669,0.000014904,0.00000262035,0.000008586262,0.00005546671,5.927521e-7,0.0001337519],"genre_scores_gemma":[0.9996686,0.00007507433,0.00006093775,0.00001849019,0.000007023099,0.000005953144,0.00008267365,5.575158e-7,0.0000807064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005758922,"threshold_uncertainty_score":0.01145077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05939322768167714,"score_gpt":0.399230719043952,"score_spread":0.3398374913622748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}