{"id":"W4385955625","doi":"10.1097/01.hs9.0000970028.58190.a6","title":"P781: EVALUATION OF PEGCETACOPLAN TREATMENT SUCCESS IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WITH AND WITHOUT BONE MARROW FAILURE: A MOVE TOWARDS INDIVIDUALIZED PATIENT TREATMENT","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Eculizumab; Bone marrow failure; Internal medicine; Myelodysplastic syndromes; Hemoglobinuria; Bone marrow; Aplastic anemia; Gastroenterology; Anemia; Immunology; Complement system; Antibody; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002978081,0.0004810668,0.001324637,0.0002779742,0.0001870715,0.0005961319,0.0004829894,0.0005309823,0.002332832],"category_scores_gemma":[0.00251192,0.0001075086,0.001040545,0.000325487,0.0002778794,0.0006455957,0.0003258236,0.0008304644,0.0003414332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006110939,"about_ca_system_score_gemma":0.00064027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001789693,"about_ca_topic_score_gemma":0.0005716518,"domain_scores_codex":[0.9987502,0.0006834744,0.0001135115,0.0001466292,0.0002228399,0.00008331804],"domain_scores_gemma":[0.9983046,0.0006375568,0.0005676281,0.00006436729,0.000159693,0.0002661097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4491332,0.005819996,0.2054384,0.001827714,0.004788107,0.000353492,0.000223741,0.002993414,0.01974683,0.0003922622,0.004254327,0.3050286],"study_design_scores_gemma":[0.04682148,0.2885202,0.6297377,0.0002815316,0.004348396,0.001161789,0.0002551683,0.006421896,0.009705147,0.0008444362,0.01181405,0.00008828123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992821,0.002790755,0.0005581096,0.0005396288,0.0000606367,0.0005673847,0.0007042961,0.00002228824,0.001935906],"genre_scores_gemma":[0.9963355,0.0006246555,0.000835959,0.0001953956,0.0001013957,0.0005360991,0.0007390284,0.000009087456,0.000622722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002978081,"threshold_uncertainty_score":0.01574981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03141361758085823,"score_gpt":0.2932572643693684,"score_spread":0.2618436467885101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}