{"id":"W4385955625","doi":"10.1097/01.hs9.0000970028.58190.a6","title":"P781: EVALUATION OF PEGCETACOPLAN TREATMENT SUCCESS IN PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WITH AND WITHOUT BONE MARROW FAILURE: A MOVE TOWARDS INDIVIDUALIZED PATIENT TREATMENT","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Eculizumab; Bone marrow failure; Internal medicine; Myelodysplastic syndromes; Hemoglobinuria; Bone marrow; Aplastic anemia; Gastroenterology; Anemia; Immunology; Complement system; Antibody; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002909192,0.000323333,0.0005864541,0.0001281907,0.00008992096,0.00002197476,0.00009488663,0.0001280622,0.00130412],"category_scores_gemma":[0.00002944721,0.0002287739,0.00008327263,0.0002819602,0.0001138569,0.00008569906,0.00006132362,0.00007003887,0.00005055263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003513184,"about_ca_system_score_gemma":0.0002878072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009329927,"about_ca_topic_score_gemma":0.002732285,"domain_scores_codex":[0.9980392,0.0004620494,0.0004872049,0.000427623,0.0001988802,0.0003850829],"domain_scores_gemma":[0.9991692,0.00007079564,0.0002659066,0.0003324074,0.0001104734,0.00005119239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002178337,0.001233618,0.9020475,0.000186996,0.001388473,0.00006083455,0.008243325,0.0004644758,0.01702637,0.0001427398,0.001623967,0.06540342],"study_design_scores_gemma":[0.06828103,0.007158732,0.7917674,0.000948759,0.002063211,0.0004730557,0.01356359,0.000645149,0.1035435,0.0004311898,0.009847917,0.001276455],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943908,0.002952399,0.000003840596,0.0001820154,0.0001412092,0.001482744,0.0002538008,0.0000680605,0.0005250946],"genre_scores_gemma":[0.9982929,0.00004842029,0.0001363198,0.00001365816,0.00001738092,0.0005358454,0.0004705687,0.00002487273,0.0004599975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.11028,"threshold_uncertainty_score":0.9996088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03141361758085823,"score_gpt":0.2932572643693684,"score_spread":0.2618436467885101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}