{"id":"W4385971625","doi":"10.1371/journal.pgen.1010874","title":"Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Science and Engineering Research Board; The Wellcome Trust DBT India Alliance; Azrieli Foundation; Israel Science Foundation; Department of Science and Technology, Ministry of Science and Technology, India; International Development Research Centre; Department of Biotechnology, Ministry of Science and Technology, India; Tata Institute of Fundamental Research; Wellcome Trust","keywords":"Biology; Transcription factor; Chromatin; Cell biology; Primordium; Axon guidance; Genetics; Hippocampal formation; Transcriptome; Gene expression; Gene; Neuroscience; Axon","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005865589,0.0001636572,0.0001631232,0.000165935,0.0001304423,0.0002743948,0.0001093841,0.00009740254,0.0006332905],"category_scores_gemma":[0.00007245948,0.0001512711,0.0001371832,0.0001062172,0.0002073842,0.0001234567,0.0003120385,0.0001890477,0.0001451688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973875,"about_ca_system_score_gemma":0.000171662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001477234,"about_ca_topic_score_gemma":0.003318689,"domain_scores_codex":[0.9999301,0.000004780496,0.000004135896,0.00002789966,0.00001578902,0.00001726145],"domain_scores_gemma":[0.9999485,0.000007903421,0.00001475489,0.000004807535,0.000005664936,0.00001832337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005458011,0.000003784129,0.001436349,0.00001088844,0.0000032255,0.00003318717,0.00002068921,0.00003000262,0.9977279,0.00003949837,0.00001729091,0.0006225765],"study_design_scores_gemma":[0.00001810014,0.00009693979,0.2578554,0.00000733883,0.00001861427,0.0002477715,0.0001356397,0.001841301,0.7372802,0.0001022666,0.002385972,0.00001042605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971613,0.0005973792,0.001084268,0.00002425603,0.000005306264,0.000005813125,0.0003738445,0.0000452537,0.0007026085],"genre_scores_gemma":[0.9956226,0.0002250188,0.00082086,0.00004308515,0.000003537154,0.00001722482,0.0006809303,0.00002301169,0.002563821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477234,"threshold_uncertainty_score":0.002937257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03561091263690002,"score_gpt":0.2931908876180257,"score_spread":0.2575799749811257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}