{"id":"W4385971625","doi":"10.1371/journal.pgen.1010874","title":"Regulation of chromatin accessibility and gene expression in the developing hippocampal primordium by LIM-HD transcription factor LHX2","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Science and Engineering Research Board; The Wellcome Trust DBT India Alliance; Azrieli Foundation; Israel Science Foundation; Department of Science and Technology, Ministry of Science and Technology, India; International Development Research Centre; Department of Biotechnology, Ministry of Science and Technology, India; Tata Institute of Fundamental Research; Wellcome Trust","keywords":"Biology; Transcription factor; Chromatin; Cell biology; Primordium; Axon guidance; Genetics; Hippocampal formation; Transcriptome; Gene expression; Gene; Neuroscience; Axon","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002539546,0.00009320563,0.000106425,0.00004569024,0.00005917836,0.00002394238,0.0001613605,0.000100413,0.000005045201],"category_scores_gemma":[0.00007197879,0.00007218253,0.00002713405,0.0001604236,0.00004979452,0.000005713026,0.00006623413,0.00006829011,0.000001252438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001267942,"about_ca_system_score_gemma":0.00004610157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004372676,"about_ca_topic_score_gemma":0.00002145024,"domain_scores_codex":[0.9990207,0.0001262455,0.0002228247,0.0002243815,0.0002172142,0.0001886665],"domain_scores_gemma":[0.9996032,0.00002458806,0.00006060089,0.0002272832,0.00004822599,0.0000361446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002874334,0.00002726311,0.0127872,0.00006433316,0.000006324335,5.068845e-7,0.0002119621,0.00002374639,0.9844791,0.000001519927,0.0001716558,0.002197609],"study_design_scores_gemma":[0.000219835,0.00006288343,0.2182209,0.00002298943,0.000003333517,8.098376e-7,0.0001066173,0.001445451,0.7796965,0.00007106541,0.00008191146,0.00006769733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979505,0.0004649817,0.001103634,0.0001395325,0.00003080207,0.0002587991,0.00002166857,0.000008598871,0.00002146998],"genre_scores_gemma":[0.9981945,0.0004277446,0.001085416,0.00002988884,0.00004918757,0.00002186958,0.0001216921,0.00001131158,0.00005834928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2054337,"threshold_uncertainty_score":0.2943518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03561091263690002,"score_gpt":0.2931908876180257,"score_spread":0.2575799749811257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}