{"id":"W4385982579","doi":"10.7554/elife.90510.1","title":"Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Mitacs; McGill University","keywords":"Endosome; Tropomyosin receptor kinase B; Spinocerebellar ataxia; Cerebellum; Biology; Cell biology; Neuroscience; Neurotrophic factors; Ataxia; Intracellular; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557499,0.0006286459,0.000371653,0.0006167435,0.0002668974,0.0002666644,0.0002017424,0.0006079183,0.001559306],"category_scores_gemma":[0.000223361,0.0001717187,0.0003858666,0.0002121668,0.0003163995,0.0002187635,0.0004026049,0.0004699547,0.0002875997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083742,"about_ca_system_score_gemma":0.0001077419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067562,"about_ca_topic_score_gemma":0.001459114,"domain_scores_codex":[0.9998988,0.00001068088,0.00001828278,0.00002510337,0.00002897653,0.00001825684],"domain_scores_gemma":[0.9997205,0.00001818055,0.0001505285,0.00001361204,0.00002482513,0.0000724147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006173718,0.000132721,0.02776126,0.0001616802,0.00007699306,0.008101481,0.0001125914,0.0002508347,0.9579229,0.0001348343,0.0001680216,0.004559363],"study_design_scores_gemma":[0.00007131525,0.000997612,0.7886642,0.00008050493,0.0002908604,0.0331188,0.0002710939,0.003245201,0.1695061,0.0006333103,0.003091391,0.00002964188],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978032,0.0008381423,0.0007234412,0.00004851915,0.00001217742,0.000009511795,0.0001636154,0.00005020648,0.0003512298],"genre_scores_gemma":[0.9984258,0.0004437754,0.0004981036,0.00002799688,0.00000780692,0.000003800177,0.0001980251,0.000009879514,0.0003847154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559306,"threshold_uncertainty_score":0.00521642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06652220065916338,"score_gpt":0.2935782261768217,"score_spread":0.2270560255176583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}