{"id":"W4385987145","doi":"10.21203/rs.3.rs-3149948/v1","title":"Fatty links between multisystem proteinopathy and Small VCP-Interacting Protein.","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; ALS Society of Canada","keywords":"Myristoylation; Amyotrophic lateral sclerosis; Frontotemporal dementia; Cell biology; Biology; Chemistry; Dementia; Disease; Medicine; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134599,0.0005442794,0.0002970001,0.0008939348,0.0003827684,0.0006305132,0.0004064859,0.0009163351,0.006747379],"category_scores_gemma":[0.0007897907,0.0001571907,0.0002389918,0.0006221561,0.0004830488,0.0003771709,0.0007023213,0.0007101227,0.0007874097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004295769,"about_ca_system_score_gemma":0.0002213801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006098493,"about_ca_topic_score_gemma":0.0002872835,"domain_scores_codex":[0.9998771,0.00003416606,0.00001145657,0.00003321302,0.00002239001,0.00002164622],"domain_scores_gemma":[0.999651,0.0001084023,0.0001166855,0.00003674319,0.00002449925,0.00006271162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009580888,0.0004363552,0.06575736,0.001798767,0.001032395,0.1373135,0.0004520814,0.002137105,0.6258121,0.05466443,0.02804178,0.07297318],"study_design_scores_gemma":[0.0008676065,0.0009966505,0.2100113,0.0003916708,0.001797738,0.2379698,0.0006419683,0.01639943,0.3339677,0.1119945,0.08482975,0.000131899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.922471,0.03828633,0.009968307,0.006295683,0.001058542,0.00005741818,0.002307325,0.00039988,0.01915546],"genre_scores_gemma":[0.9890332,0.003561621,0.001231451,0.0002305915,0.0002543466,0.00002200388,0.0007640072,0.00002404015,0.004878628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006747379,"threshold_uncertainty_score":0.02257216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08771044023180556,"score_gpt":0.3823202855442989,"score_spread":0.2946098453124933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}