{"id":"W4385987383","doi":"10.1038/s41467-023-40271-4","title":"Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Toronto; University of Calgary","funders":"University of Calgary","keywords":"Computational biology; Transcriptome; Core (optical fiber); Biology; Computer science; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500921,0.0001778697,0.0002853789,0.0003799034,0.0001163252,0.0004037438,0.0001066599,0.0002238778,0.000515331],"category_scores_gemma":[0.0002903139,0.0001225629,0.0002520279,0.0004052575,0.0002065195,0.0002444994,0.0001735463,0.0001937472,0.0001640086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003126516,"about_ca_system_score_gemma":0.0002462596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001931589,"about_ca_topic_score_gemma":0.003509387,"domain_scores_codex":[0.9999018,0.00001089623,0.000004950974,0.0000370961,0.00002638061,0.00001891163],"domain_scores_gemma":[0.9999135,0.00002573832,0.00002819911,0.00001000926,0.00001545619,0.000006988602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001993635,0.00003020938,0.04991399,0.0001037132,0.00005164494,0.00007820303,0.0001025076,0.01670688,0.9177464,0.0007134016,0.0003285165,0.01402513],"study_design_scores_gemma":[0.00001486484,0.0002361286,0.469754,0.00002578309,0.00015286,0.0003701803,0.0006986685,0.1830125,0.3383322,0.003151788,0.004194955,0.00005604178],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778973,0.0004963241,0.01730349,0.00008954718,0.000006880415,0.00001653223,0.002851415,0.0002311818,0.001107241],"genre_scores_gemma":[0.9922455,0.0002829818,0.005601638,0.00003011451,0.000003178641,0.00002226725,0.001393621,0.00003389743,0.0003867529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001931589,"threshold_uncertainty_score":0.003840744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03922616198878399,"score_gpt":0.2837891786525699,"score_spread":0.2445630166637859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}