{"id":"W4385988582","doi":"10.1016/j.ajogmf.2023.101124","title":"Pharmacological blockade of the interleukin-1 receptor suppressed Escherichia coli lipopolysaccharide-induced neuroinflammation in preterm fetal sheep","year":2023,"lang":"en","type":"article","venue":"American Journal of Obstetrics & Gynecology MFM","topic":"Preterm Birth and Chorioamnionitis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Université de Montréal","funders":"National Health and Medical Research Council; Stan Perron Charitable Foundation; Women and Infants Research Foundation","keywords":"Chorioamnionitis; Medicine; Inflammation; Anakinra; Interleukin 1 receptor antagonist; Lipopolysaccharide; Systemic inflammation; Fetus; Internal medicine; Gestation; Receptor antagonist; Anesthesia; Immunology; Endocrinology; Receptor; Antagonist; Pregnancy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365689,0.0002709381,0.0004596473,0.0001998009,0.0001700225,0.0003166762,0.0002581265,0.0003979799,0.001654304],"category_scores_gemma":[0.0004169738,0.0001595983,0.0002188647,0.00008826807,0.0004829869,0.0002504808,0.0001556159,0.0009817432,0.0005196658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762707,"about_ca_system_score_gemma":0.000283947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004935845,"about_ca_topic_score_gemma":0.0007183477,"domain_scores_codex":[0.9998467,0.0000324524,0.00002107658,0.00002463002,0.00002142041,0.00005365294],"domain_scores_gemma":[0.9997689,0.00006097096,0.00005490525,0.00002999458,0.00002398191,0.00006127623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003137492,0.0001992051,0.0001948979,0.00009210849,0.00001025023,0.0002055119,0.00007379072,0.00006845287,0.9923003,0.0001014246,0.00008609964,0.003530569],"study_design_scores_gemma":[0.0004325922,0.008586718,0.006968421,0.00005301841,0.00007601479,0.0008486,0.0003022709,0.001260453,0.9772825,0.000210788,0.003956699,0.00002209474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956738,0.001693728,0.001181051,0.0002819008,0.0001009991,0.00002680141,0.0001707283,0.00004437941,0.0008266359],"genre_scores_gemma":[0.9932449,0.001732929,0.001464982,0.0001296581,0.00007458232,0.00008183902,0.0002215258,0.00001949867,0.003029954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654304,"threshold_uncertainty_score":0.005534172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01739811800023129,"score_gpt":0.2760893155301963,"score_spread":0.2586911975299651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}