{"id":"W4386012742","doi":"10.1016/j.pediatrneurol.2023.08.019","title":"Treatment of Refractory Epilepsy With MEK Inhibitor in Patients With RASopathy","year":2023,"lang":"en","type":"article","venue":"Pediatric Neurology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trametinib; Discontinuation; Medicine; Epilepsy; Levetiracetam; Pediatrics; Refractory (planetary science); Internal medicine; Oncology; MAPK/ERK pathway; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170821,0.0003287986,0.0004873677,0.0002250141,0.000262549,0.0002448392,0.0002049694,0.0003100215,0.0008549421],"category_scores_gemma":[0.0003621779,0.00006157346,0.0003945049,0.0001882878,0.00013798,0.0002213035,0.0001178097,0.0005822403,0.0002019108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111291,"about_ca_system_score_gemma":0.0004175615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007239428,"about_ca_topic_score_gemma":0.002245557,"domain_scores_codex":[0.9999409,0.00001202884,0.000009830078,0.000007800982,0.000008787758,0.00002075003],"domain_scores_gemma":[0.9999182,0.00001924078,0.00001916453,0.000004682918,0.000007272717,0.00003132686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.02948857,0.001813591,0.209595,0.00125484,0.001367962,0.1219285,0.0005706244,0.002531422,0.08538874,0.00216618,0.01449447,0.5294001],"study_design_scores_gemma":[0.005247859,0.01797559,0.5909372,0.0007370673,0.002147757,0.2758018,0.001095434,0.005357234,0.03822142,0.005569502,0.05674152,0.0001675917],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690402,0.01871496,0.0009627565,0.002002262,0.0001881127,0.00006698837,0.0002772765,0.00009599184,0.008651489],"genre_scores_gemma":[0.994211,0.00358979,0.0004412291,0.0004788336,0.00007074863,0.00002899301,0.0002614136,0.000006890411,0.0009110831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008549421,"threshold_uncertainty_score":0.002860069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005595701158758129,"score_gpt":0.1952676439485771,"score_spread":0.189671942789819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}