{"id":"W4386012994","doi":"10.1016/j.bcp.2023.115758","title":"An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules","year":2023,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Council Canada; KU Leuven; Fonds Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Neurotoxin; Nicotinic acetylcholine receptor; Venom; Nicotinic agonist; Pharmacology; Snake venom; Acetylcholine receptor; Antivenom; Biology; Neurotoxicity; Receptor; Chemistry; Biochemistry; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00201604,0.002108872,0.00145529,0.000942717,0.0005906448,0.001199041,0.001170887,0.001494488,0.002219434],"category_scores_gemma":[0.001513753,0.0007364745,0.001286517,0.001155844,0.0005070594,0.0007697142,0.0009636993,0.002440806,0.002928271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003647721,"about_ca_system_score_gemma":0.0006024382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007397034,"about_ca_topic_score_gemma":0.001429129,"domain_scores_codex":[0.9952686,0.001291574,0.0006873131,0.0006702387,0.001808987,0.0002732134],"domain_scores_gemma":[0.9984238,0.0006235258,0.000236712,0.0002490743,0.000383621,0.0000832095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000580788,0.0001783897,0.0001842589,0.0001822314,0.00002042007,0.00003793154,0.00004982105,0.00009705271,0.9973876,0.0000883199,0.00008570902,0.001630188],"study_design_scores_gemma":[0.00001634831,0.001131911,0.001216796,0.00003626237,0.00007050504,0.0002431066,0.00004419066,0.001067251,0.9933764,0.00006739158,0.00271443,0.00001534852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4837217,0.01630323,0.4728542,0.0008962263,0.001279347,0.002833918,0.005822803,0.001779263,0.01450934],"genre_scores_gemma":[0.625405,0.02340528,0.3091173,0.0007420781,0.0004029448,0.005083453,0.0141984,0.0004135799,0.021232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002219434,"threshold_uncertainty_score":0.01066196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03006577358311104,"score_gpt":0.323625578948844,"score_spread":0.293559805365733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}