{"id":"W4386019328","doi":"10.1016/j.celrep.2023.113012","title":"The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Queen's University Belfast; Medical Research Council; Directorate for Biological Sciences; Wellcome Trust; Academy of Medical Sciences; Queen's University","keywords":"Pyroptosis; Inflammasome; NLRC4; Secretion; Achromobacter; Intracellular; Biology; Cell biology; Microbiology; Innate immune system; Phagocytosis; Immune system; Inflammation; Caspase 1; Immunology; Bacteria; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863067,0.00009434062,0.0001100626,0.0000328597,0.00008132688,0.00001873697,0.00004014172,0.0001257475,0.000001826286],"category_scores_gemma":[0.00004508335,0.0000724461,0.0000295028,0.00007224323,0.00007646182,0.000005141792,0.0001004504,0.00005311365,0.000001325843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009789321,"about_ca_system_score_gemma":0.00003364918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001430915,"about_ca_topic_score_gemma":0.000006099733,"domain_scores_codex":[0.9992591,0.00005470786,0.0002339436,0.000227464,0.00009033553,0.0001344231],"domain_scores_gemma":[0.9994388,0.00001705515,0.0001767001,0.0002587602,0.00006947512,0.00003924469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000248079,0.000006065146,0.009411621,0.00004722437,0.00001825578,0.00002369847,0.00007957724,0.000006367588,0.9886239,0.0000126241,0.00006209409,0.001683745],"study_design_scores_gemma":[0.0001309055,0.0001364011,0.06217006,0.00001776453,0.00001802738,0.0001116073,0.0003591805,0.00005618214,0.9337804,0.00003359693,0.003088279,0.00009760428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985693,0.0004854157,0.00008796473,0.00003618759,0.0001560556,0.0001320442,0.000001063869,0.00001633364,0.0005156151],"genre_scores_gemma":[0.9987507,0.0005968604,0.00001900583,0.000010615,0.00005758597,0.00001417024,0.00005713046,0.00001316764,0.0004807197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05484353,"threshold_uncertainty_score":0.2954266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00479238816220269,"score_gpt":0.206843346125808,"score_spread":0.2020509579636053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}