{"id":"W4386021597","doi":"10.1097/01.hs9.0000968124.64352.6e","title":"S303: A PHASE 3 STUDY (ATLAS-PPX) TO EVALUATE EFFICACY AND SAFETY OF FITUSIRAN IN PEOPLE WITH HAEMOPHILIA A OR B WHO HAVE SWITCHED FROM PRIOR CLOTTING FACTOR CONCENTRATE OR BYPASSING AGENT PROPHYLAXIS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Medicine; Tolerability; Haemophilia; Haemophilia B; Adverse effect; Clotting factor; Haemophilia A; Clinical endpoint; Internal medicine; Surgery; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004085685,0.0003636664,0.0009309174,0.0001505075,0.0001571144,0.0000548668,0.000132199,0.0001195701,0.000732871],"category_scores_gemma":[0.0005136567,0.0002119253,0.00006588501,0.00108777,0.00009294169,0.00009455494,0.0001481152,0.000316112,0.00004384385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002018189,"about_ca_system_score_gemma":0.0005935576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006753209,"about_ca_topic_score_gemma":0.002524674,"domain_scores_codex":[0.9970475,0.0001890604,0.0006140774,0.0007137965,0.0007922082,0.0006433856],"domain_scores_gemma":[0.9983451,0.0004846007,0.0001367547,0.0004708421,0.0001584565,0.0004042235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04984589,0.005297045,0.6776065,0.0009930745,0.001017153,0.00473117,0.08266785,0.00008945784,0.05518519,0.00000202865,0.0003971734,0.1221675],"study_design_scores_gemma":[0.08474535,0.01909982,0.8326381,0.003417009,0.0004222498,0.00004509544,0.02596514,0.004706423,0.02778956,0.000009879588,0.000437954,0.0007233591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939802,0.0001892366,0.00001668863,0.0007335026,0.00004377714,0.004776917,0.00005240882,0.00008929595,0.0001180088],"genre_scores_gemma":[0.995653,0.00006554713,0.0005373822,0.00004336696,0.0000926443,0.0001498482,0.00004280156,0.00006640644,0.003349043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1550317,"threshold_uncertainty_score":0.8642065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06836513171879907,"score_gpt":0.3728361111625864,"score_spread":0.3044709794437873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}