{"id":"W4386021670","doi":"10.1097/01.hs9.0000967980.32472.94","title":"S267: PHARMACOKINETICS/PHARMACODYNAMICS, SAFETY AND EFFICACY OF CRIZANLIZUMAB IN PATIENTS WITH SICKLE CELL DISEASE AGED 12 TO <18 YEARS: 2-YEAR DATA FROM THE PHASE 2 SOLACE-KIDS STUDY","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"","keywords":"Medicine; Tolerability; Dosing; Pharmacokinetics; Pharmacodynamics; Adverse effect; Clinical trial; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206454,0.0002270503,0.0003649021,0.00005790649,0.00007199783,0.00002055029,0.0003051653,0.00006065996,0.0005198496],"category_scores_gemma":[0.0001209822,0.000159006,0.00004025401,0.0004950638,0.00009680502,0.00008109736,0.0003561483,0.000309292,0.00006252299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003618983,"about_ca_system_score_gemma":0.0001074137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001758618,"about_ca_topic_score_gemma":0.00009112073,"domain_scores_codex":[0.9982327,0.0001153622,0.000385606,0.0005143404,0.0004194129,0.0003326311],"domain_scores_gemma":[0.9985549,0.0001818883,0.00009138175,0.0008176115,0.00005378778,0.0003003875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03503044,0.01569088,0.8410999,0.0004457645,0.00079504,0.0007989326,0.01128752,0.001523524,0.001688377,0.000009339692,0.05201585,0.03961441],"study_design_scores_gemma":[0.07184149,0.001354422,0.9068826,0.0003295827,0.0008340412,7.192704e-7,0.005235769,0.005512647,0.00008173857,0.000008794615,0.007513738,0.0004044985],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960052,0.0004098103,0.0000299128,0.0003733138,0.0001280895,0.001764293,0.0006831677,0.00006916128,0.0005370428],"genre_scores_gemma":[0.9980786,0.0003259169,0.0001114813,0.000240495,0.00005809671,0.0000130214,0.0007755778,0.000056671,0.0003400885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06578264,"threshold_uncertainty_score":0.6484075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948532737350761,"score_gpt":0.2944407052088396,"score_spread":0.274955377835332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}