{"id":"W4386022333","doi":"10.1021/acsinfecdis.3c00217","title":"Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada","keywords":"Tobramycin; Aztreonam; Pseudomonas aeruginosa; Ceftazidime; Microbiology; Aminoglycoside; Chemistry; Antibiotics; Bacteria; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006065337,0.0003295898,0.000160409,0.00008987221,0.00005746805,0.000146765,0.0001313983,0.0001776164,0.0005260813],"category_scores_gemma":[0.00007422027,0.00008471082,0.0001413514,0.00007214418,0.0001039878,0.0001253002,0.0001332048,0.0002542992,0.0001633801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050226,"about_ca_system_score_gemma":0.0001154752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000361481,"about_ca_topic_score_gemma":0.0007854204,"domain_scores_codex":[0.9999365,0.00001598877,0.000005076774,0.000009592053,0.00001448717,0.00001834301],"domain_scores_gemma":[0.9999598,0.000004462359,0.00001487154,0.000003701144,0.000004936674,0.00001221505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001451642,0.0000458849,0.0000897855,0.00003067527,0.000004201579,0.00002487916,0.000007158082,0.0001078282,0.996866,0.00003315696,0.00003134666,0.002613826],"study_design_scores_gemma":[0.00004191429,0.001550831,0.002204648,0.000006373773,0.00001964174,0.0001403185,0.00001219822,0.000606727,0.9932186,0.00001250676,0.002179476,0.000006776246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966126,0.001103864,0.0007498068,0.00004144771,0.00001687806,0.0000382211,0.00006144766,0.00005427021,0.001321453],"genre_scores_gemma":[0.9978164,0.0005387897,0.001002975,0.00002715134,0.00000523758,0.00001462719,0.00007105411,0.000007660009,0.0005161193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005260813,"threshold_uncertainty_score":0.001759887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006544549846423733,"score_gpt":0.2309878408511533,"score_spread":0.2244432910047296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}