{"id":"W4386022333","doi":"10.1021/acsinfecdis.3c00217","title":"Guanidinylated Amphiphilic Tobramycin Derivatives Synergize with β-Lactam/β-Lactamase Inhibitor Combinations against <i>Pseudomonas aeruginosa</i>","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada","keywords":"Tobramycin; Aztreonam; Pseudomonas aeruginosa; Ceftazidime; Microbiology; Aminoglycoside; Chemistry; Antibiotics; Bacteria; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001086887,0.0003740653,0.0002917898,0.0001627854,0.0003451338,0.0001240116,0.0002583293,0.0001775716,0.00002869157],"category_scores_gemma":[0.0004212249,0.0003404478,0.0001263797,0.0007201787,0.000335114,0.00003011442,0.0001742063,0.0001375502,0.00008776064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000613486,"about_ca_system_score_gemma":0.0002161109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002258032,"about_ca_topic_score_gemma":0.00007381146,"domain_scores_codex":[0.9980921,0.000132611,0.0003245963,0.0006292852,0.0002715099,0.0005498529],"domain_scores_gemma":[0.9986472,0.00009602627,0.0001832388,0.0006197197,0.0002127652,0.0002410973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003544565,0.00100803,0.3901209,0.0001360914,0.0004713604,0.0001367488,0.0001227181,0.0004496082,0.5842132,0.001345207,0.02043503,0.001206665],"study_design_scores_gemma":[0.008867173,0.002144915,0.5671299,0.0004181398,0.0004190638,0.00009898478,0.0008482637,0.0001630665,0.3926529,0.001865264,0.02263371,0.002758581],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964979,0.0002362526,0.0001556947,0.0002905733,0.0002690498,0.0004386313,0.0001575652,0.0003688773,0.001585399],"genre_scores_gemma":[0.9969503,0.000491995,0.00004436608,0.000439684,0.0002574227,0.00007308019,0.001094617,0.00008393073,0.0005645573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1915603,"threshold_uncertainty_score":0.9999048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006544549846423733,"score_gpt":0.2309878408511533,"score_spread":0.2244432910047296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}