{"id":"W4386022834","doi":"10.21203/rs.3.rs-3201401/v1","title":"Robust Bioprocess Design and Evaluation of Commercial Media for the Serial Expansion of Human Induced Pluripotent Stem Cell Aggregate Cultures in Vertical-Wheel Bioreactors","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Bioprocess; Induced pluripotent stem cell; Bioreactor; Biochemical engineering; Human Induced Pluripotent Stem Cells; Aggregate (composite); Bioprocess engineering; Biotechnology; Engineering; Biology; Nanotechnology; Materials science; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002230591,0.0008488658,0.0005044304,0.0008728178,0.000444988,0.001848918,0.0008124831,0.0005825043,0.0009958636],"category_scores_gemma":[0.002756104,0.0002815848,0.0005062236,0.0006065741,0.0003610384,0.0005645187,0.0007689313,0.0004025165,0.0006108263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007718829,"about_ca_system_score_gemma":0.0006664085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009038252,"about_ca_topic_score_gemma":0.001400121,"domain_scores_codex":[0.998672,0.0001942969,0.0002082209,0.0001952117,0.0006426979,0.00008750593],"domain_scores_gemma":[0.9983969,0.0003578637,0.0003319,0.0001544093,0.0006614995,0.00009737782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002253796,0.0001034881,0.0005270615,0.0001436739,0.00001460949,0.0000353528,0.00003470517,0.001124028,0.9888698,0.0001359057,0.0001440612,0.008641859],"study_design_scores_gemma":[0.00001353369,0.0003090305,0.0009965386,0.00001478815,0.00002945477,0.00002748051,0.00002984054,0.002901174,0.9942951,0.00004360175,0.001327132,0.0000122996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8794641,0.005543781,0.1075822,0.0003658878,0.0002747252,0.001111833,0.00211073,0.0009724455,0.002574284],"genre_scores_gemma":[0.8721907,0.003497613,0.1162084,0.0001468674,0.00008659909,0.001208558,0.002805157,0.0003350563,0.003521143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002230591,"threshold_uncertainty_score":0.01179659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2203512530559817,"score_gpt":0.4120862486273827,"score_spread":0.191734995571401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}