{"id":"W4386023724","doi":"10.20944/preprints202308.1414.v1","title":"PNA6, a Lactosyl Analogue of Angiotensin-(1—7), Reverses Pain Induced in Murine Models of Inflammation, Metastatic Bone Disease, and Chemotherapy-Induced Peripheral Neuropathy","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Beetle Biology and Toxicology Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Arizona; Arizona Biomedical Research Commission; Partenariat Canadien Contre Le Cancer; National Institute on Drug Abuse; International Association for the Study of Pain; Cancer Research Institute","keywords":"Medicine; Peripheral neuropathy; Oxaliplatin; Chemotherapy; Pharmacology; Endocrinology; Bone pain; Internal medicine; Cancer; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009692052,0.0003611705,0.0007124105,0.000188346,0.00004683309,0.000004003654,0.000262098,0.0003937574,0.00001495747],"category_scores_gemma":[0.0007826216,0.0003638793,0.0001859196,0.0001591601,0.0002543802,0.000008549375,0.001004056,0.000376654,0.000003307269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002254287,"about_ca_system_score_gemma":0.0001813747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001774983,"about_ca_topic_score_gemma":0.0002478685,"domain_scores_codex":[0.9974982,0.0005554241,0.0007044618,0.0008181921,0.0001391745,0.000284578],"domain_scores_gemma":[0.9983949,0.00008247676,0.0004871831,0.000739455,0.0002031198,0.00009284454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005125313,0.0001589236,0.3145439,0.0003342232,0.0005220147,0.00003035647,0.0004288825,0.0009084825,0.6821243,0.00005543942,0.00003382545,0.0003470872],"study_design_scores_gemma":[0.001034849,0.0001800616,0.8357717,0.0001701862,0.0001372205,0.000005295401,0.0001272626,0.0007574772,0.1597262,0.001621863,0.00008666229,0.0003811105],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976804,0.0005042453,0.0001092874,0.0007665666,0.0001635814,0.0006144215,0.00007924436,0.00002585148,0.00005644569],"genre_scores_gemma":[0.9980448,0.001116945,0.0001423644,0.0001687664,0.0000902285,0.00009902925,0.0001886763,0.00004296603,0.00010624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5223981,"threshold_uncertainty_score":0.9998813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1071006091452612,"score_gpt":0.3205394185780173,"score_spread":0.2134388094327561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}