{"id":"W4386023724","doi":"10.20944/preprints202308.1414.v1","title":"PNA6, a Lactosyl Analogue of Angiotensin-(1—7), Reverses Pain Induced in Murine Models of Inflammation, Metastatic Bone Disease, and Chemotherapy-Induced Peripheral Neuropathy","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Beetle Biology and Toxicology Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Arizona; Arizona Biomedical Research Commission; Partenariat Canadien Contre Le Cancer; National Institute on Drug Abuse; International Association for the Study of Pain; Cancer Research Institute","keywords":"Medicine; Peripheral neuropathy; Oxaliplatin; Chemotherapy; Pharmacology; Endocrinology; Bone pain; Internal medicine; Cancer; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000173052,0.00060538,0.0004537395,0.0003962372,0.0001473005,0.000174296,0.0002980912,0.0003818384,0.001161344],"category_scores_gemma":[0.00008402592,0.0001560609,0.0003048262,0.0001778882,0.0003119097,0.0003571922,0.0001382217,0.001698426,0.0002691538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114379,"about_ca_system_score_gemma":0.0003487008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005208416,"about_ca_topic_score_gemma":0.001216749,"domain_scores_codex":[0.9998671,0.00001943402,0.000009575374,0.0000257678,0.00003974716,0.00003850553],"domain_scores_gemma":[0.999873,0.00001046617,0.00004768137,0.000007286175,0.00001167713,0.00004987062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006648691,0.0003756813,0.00009842587,0.000109917,0.00001151689,0.00004652254,0.00001280052,0.000134768,0.9947885,0.0001156323,0.00008309224,0.00355813],"study_design_scores_gemma":[0.0001747073,0.01023219,0.002367273,0.00001822341,0.00004866705,0.0002495778,0.00003461684,0.0008685961,0.982559,0.00006560294,0.003371673,0.000009835127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852766,0.005827833,0.004814685,0.0003375666,0.0002373704,0.0001604584,0.0008079717,0.0002525767,0.002284789],"genre_scores_gemma":[0.9834925,0.005474894,0.005201471,0.0001835355,0.00005204974,0.0001523081,0.0008595693,0.00002714348,0.004556478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161344,"threshold_uncertainty_score":0.003885031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1071006091452612,"score_gpt":0.3205394185780173,"score_spread":0.2134388094327561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}