{"id":"W4386023903","doi":"10.1097/01.hs9.0000968792.87320.b0","title":"P471: POLO-LIKE KINASE 4 INHIBITION INDUCED ANTI-LEUKAEMIC EFFECTS THROUGH HISTONE MODIFICATION IN TP53 MUTATED ACUTE MYELOID LEUKAEMIA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Health and Medical Research Fund; Innovation and Technology Commission; Li Shu Fan Medical Foundation","keywords":"Biology; Transcriptome; Cancer research; Myeloid leukemia; Gene; Epigenetics; Haematopoiesis; Myeloid; Genetics; Gene expression; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008148739,0.0002572631,0.0003199967,0.0002333287,0.0001520037,0.00022342,0.000106987,0.0001712522,0.002072464],"category_scores_gemma":[0.00007599659,0.00008100571,0.0002706956,0.0002587154,0.0001761613,0.0001311654,0.0001421385,0.000378977,0.0003285357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240967,"about_ca_system_score_gemma":0.000208993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000323766,"about_ca_topic_score_gemma":0.0003730532,"domain_scores_codex":[0.9999102,0.00000768977,0.000006427359,0.00002316326,0.00002757602,0.00002497271],"domain_scores_gemma":[0.9999694,0.000004606996,0.00001199667,0.000002520447,0.000003349897,0.000008099244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004981116,0.00004500735,0.0006195269,0.00008929643,0.00001052855,0.00005287577,0.000009886292,0.0001371702,0.9953316,0.00003467347,0.0001208183,0.003050423],"study_design_scores_gemma":[0.00007531515,0.0009631196,0.02487255,0.0000115321,0.00006248795,0.0002930541,0.0000429893,0.001733471,0.9675954,0.0000865042,0.004257259,0.000006281055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994531,0.00216596,0.0009820934,0.0001338974,0.00004497037,0.00002679205,0.001213954,0.00008224374,0.000819201],"genre_scores_gemma":[0.9928675,0.001322931,0.0009445638,0.0001071661,0.00001355774,0.00005268424,0.002529139,0.00002132939,0.002141154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072464,"threshold_uncertainty_score":0.006933033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03625720728268949,"score_gpt":0.3450904574119436,"score_spread":0.3088332501292541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}