{"id":"W4386023903","doi":"10.1097/01.hs9.0000968792.87320.b0","title":"P471: POLO-LIKE KINASE 4 INHIBITION INDUCED ANTI-LEUKAEMIC EFFECTS THROUGH HISTONE MODIFICATION IN TP53 MUTATED ACUTE MYELOID LEUKAEMIA","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Health and Medical Research Fund; Innovation and Technology Commission; Li Shu Fan Medical Foundation","keywords":"Biology; Transcriptome; Cancer research; Myeloid leukemia; Gene; Epigenetics; Haematopoiesis; Myeloid; Genetics; Gene expression; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000514762,0.000466743,0.0007695882,0.0004056883,0.0001795246,0.0000440128,0.0002315191,0.0005578127,0.0002544681],"category_scores_gemma":[0.0003446528,0.0004568389,0.0001765514,0.002822767,0.0001834092,0.0004339783,0.0001919463,0.001146465,0.001997749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002141251,"about_ca_system_score_gemma":0.0007093404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097108,"about_ca_topic_score_gemma":0.00009887251,"domain_scores_codex":[0.9963151,0.0002313619,0.0006890229,0.000926991,0.0008058375,0.001031747],"domain_scores_gemma":[0.9981242,0.0002548657,0.0001958095,0.0009121718,0.0002241144,0.0002887966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005360556,0.0002697968,0.002473089,0.0007223415,0.0001459895,0.003256605,0.001477416,0.0000791964,0.9614264,0.0004798007,0.02377828,0.005355042],"study_design_scores_gemma":[0.01621323,0.0009798062,0.0998792,0.00157103,0.0003603676,0.0006378027,0.001396179,0.008718316,0.8645332,0.001265501,0.003247106,0.001198239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915198,0.0003214125,0.0001743508,0.002256473,0.0003214003,0.001766068,0.00002372549,0.0007406087,0.002876133],"genre_scores_gemma":[0.993595,0.0004126386,0.0007754425,0.0007813074,0.0002074637,0.0003406665,0.0009706411,0.000144097,0.002772732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09740611,"threshold_uncertainty_score":0.9997883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03625720728268949,"score_gpt":0.3450904574119436,"score_spread":0.3088332501292541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}