{"id":"W4386024071","doi":"10.1097/01.hs9.0000967904.29417.23","title":"S248: SIERRA TRIAL RESULTS WITH A TARGETED RADIOTHERAPY, IOMAB-B, A MYELOABLATIVE CONDITIONING WITH REDUCED INTENSITY TOLERABILITY YIELDS HIGH CR, LONG TERM SURVIVAL IN HSCT INELIGIBLE ACTIVE R/R AML","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ottawa Hospital","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Fludarabine; Clinical endpoint; Hematopoietic stem cell transplantation; Population; Oncology; Transplantation; Total body irradiation; Randomized controlled trial; Gastroenterology; Surgery; Adverse effect; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009991932,0.0005101245,0.001241201,0.0003169658,0.0002191359,0.00007537517,0.000248176,0.0003590154,0.0003508402],"category_scores_gemma":[0.0008492776,0.0003824496,0.000131671,0.002493527,0.0004756264,0.0003515877,0.0001259923,0.001343919,0.00004003427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001403903,"about_ca_system_score_gemma":0.001392393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001706078,"about_ca_topic_score_gemma":0.001368351,"domain_scores_codex":[0.9958684,0.0003610293,0.0007187319,0.001114249,0.0009620719,0.0009755584],"domain_scores_gemma":[0.9972767,0.0005971416,0.0002901568,0.0008592434,0.0006177599,0.0003590122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8497469,0.001595748,0.06599729,0.0006592675,0.002212812,0.006374273,0.01738575,0.001026248,0.04117372,0.0002177515,0.006505055,0.007105154],"study_design_scores_gemma":[0.1951602,0.007044882,0.7456954,0.00146464,0.0001882986,0.0002725666,0.005576326,0.001836619,0.04136657,0.000165063,0.0002030425,0.001026396],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909659,0.00006328938,0.0002859533,0.002422662,0.0001979677,0.002741201,0.00008596321,0.0003667647,0.002870322],"genre_scores_gemma":[0.9945917,0.00004882049,0.001518373,0.0001804069,0.0003960871,0.0002875845,0.0005334014,0.0001072879,0.002336299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6796982,"threshold_uncertainty_score":0.9998627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03122284311210522,"score_gpt":0.3114139022138427,"score_spread":0.2801910591017375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}