{"id":"W4386024250","doi":"10.1016/s1473-3099(23)00393-6","title":"Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Emergent BioSolutions (Canada); Immune Biosolutions (Canada)","funders":"Strategic Innovation Fund","keywords":"Coronavirus disease 2019 (COVID-19); Placebo; Medicine; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Double blind; Randomized controlled trial; Phase (matter); Internal medicine; Anesthesia; Virology; Alternative medicine; Pathology; Chemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002092568,0.00294599,0.006393592,0.0004787041,0.0006762633,0.001839428,0.001437578,0.0042263,0.008191058],"category_scores_gemma":[0.002345557,0.001309479,0.002924629,0.0004900045,0.00227506,0.001705738,0.0005782923,0.004949871,0.002100821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008230963,"about_ca_system_score_gemma":0.00116756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009706236,"about_ca_topic_score_gemma":0.0015002,"domain_scores_codex":[0.998938,0.0004884043,0.00006097213,0.0002167407,0.00008283571,0.0002129615],"domain_scores_gemma":[0.9989197,0.0002982311,0.0002160745,0.0001127645,0.00007945843,0.0003737049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9895271,0.002288741,0.0001767709,0.0004272726,0.0005654519,0.00002271189,0.00002369435,0.00008035205,0.001942474,0.0000554871,0.0005146291,0.004375259],"study_design_scores_gemma":[0.9759601,0.0225903,0.0005647057,0.00002045725,0.0002506318,0.0000124322,0.000009025581,0.0001030264,0.0001410647,0.00007707251,0.0002582284,0.00001310144],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719146,0.01160282,0.001358743,0.001590765,0.001713012,0.005897293,0.002041721,0.0003009669,0.003580109],"genre_scores_gemma":[0.9777743,0.00451142,0.001787558,0.002496487,0.001048978,0.005474631,0.001855476,0.00007989116,0.004971308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008191058,"threshold_uncertainty_score":0.0274018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08882256858103217,"score_gpt":0.4181474074402153,"score_spread":0.3293248388591831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}