{"id":"W4386024250","doi":"10.1016/s1473-3099(23)00393-6","title":"Safety and efficacy of inhaled IBIO123 for mild-to-moderate COVID-19: a randomised, double-blind, dose-ascending, placebo-controlled, phase 1/2 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Emergent BioSolutions (Canada); Immune Biosolutions (Canada)","funders":"Strategic Innovation Fund","keywords":"Coronavirus disease 2019 (COVID-19); Placebo; Medicine; 2019-20 coronavirus outbreak; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Double blind; Randomized controlled trial; Phase (matter); Internal medicine; Anesthesia; Virology; Alternative medicine; Pathology; Chemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001688822,0.0003351055,0.001457551,0.00044865,0.0004316111,0.00009862611,0.0002543966,0.000123146,0.00003414886],"category_scores_gemma":[0.003627499,0.0002240796,0.0004650514,0.0007973648,0.0002352941,0.00007992349,0.0001310453,0.0002436284,0.00005104305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538,"about_ca_system_score_gemma":0.0007619448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001699426,"about_ca_topic_score_gemma":0.00006413853,"domain_scores_codex":[0.997354,0.0002854231,0.0006531535,0.0005271398,0.0004893155,0.0006909492],"domain_scores_gemma":[0.9950845,0.003553555,0.0002204945,0.0006484053,0.000178124,0.0003149099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9890644,0.0009268332,0.001404575,0.0004483193,0.0007353019,0.00006247991,0.00045022,0.000078314,0.001490749,0.0002859382,0.003187489,0.001865361],"study_design_scores_gemma":[0.9721958,0.001753793,0.0001526064,0.00008488585,0.0008160449,0.00003480377,0.00007742142,0.001589723,0.001486088,0.0004400653,0.0211222,0.00024657],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814118,0.0005921413,0.000726236,0.001795844,0.0003162869,0.01332718,0.0002745024,0.0004827416,0.001073297],"genre_scores_gemma":[0.9803888,0.0001260093,0.0000128774,0.01564946,0.001309344,0.00226501,0.00006161421,0.00006208197,0.0001248034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01793471,"threshold_uncertainty_score":0.9137702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08882256858103217,"score_gpt":0.4181474074402153,"score_spread":0.3293248388591831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}