{"id":"W4386024295","doi":"10.1016/s2213-8587(23)00193-6","title":"Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study","year":2023,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Associazione Italiana per la Ricerca sul Cancro; Cancer Research UK; Ministère des Affaires Sociales et de la Santé; Deutsche Forschungsgemeinschaft; Agenzia Italiana del Farmaco, Ministero della Salute; Academy of Medical Sciences","keywords":"Mitotane; Medicine; Adrenocortical carcinoma; Clinical endpoint; Observational study; Adjuvant; Internal medicine; Intention-to-treat analysis; Randomized controlled trial; Surgery; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005272566,0.001278057,0.003793101,0.0003741605,0.000554183,0.001403277,0.00108766,0.001883039,0.002518285],"category_scores_gemma":[0.004503089,0.000554598,0.002959527,0.000693656,0.001293193,0.0008299059,0.0007053353,0.002350284,0.0003475114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000954087,"about_ca_system_score_gemma":0.001688916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248649,"about_ca_topic_score_gemma":0.002059976,"domain_scores_codex":[0.9972248,0.001984808,0.0001572016,0.0002704648,0.0001325689,0.0002302827],"domain_scores_gemma":[0.9959363,0.00122081,0.001260792,0.0003476253,0.0002120451,0.00102252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9859261,0.004566074,0.001928801,0.0004914416,0.0009570181,0.0000162073,0.0000450711,0.0001600174,0.001002593,0.00003858795,0.0001650347,0.004703013],"study_design_scores_gemma":[0.8936774,0.1005543,0.004051346,0.00004551121,0.0008408734,0.00002724566,0.00002687926,0.0001682806,0.000170504,0.00007426118,0.0003518212,0.00001165585],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892754,0.006235096,0.0003594098,0.0002945723,0.0002758392,0.002378966,0.0004761165,0.00002576808,0.000678823],"genre_scores_gemma":[0.9916653,0.002113487,0.0009887862,0.0005764498,0.0004779853,0.003007837,0.0006180875,0.000008568059,0.000543431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005272566,"threshold_uncertainty_score":0.0278843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.189676285825029,"score_gpt":0.4136935625130954,"score_spread":0.2240172766880664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}