{"id":"W4386024295","doi":"10.1016/s2213-8587(23)00193-6","title":"Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study","year":2023,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Adrenal and Paraganglionic Tumors","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Associazione Italiana per la Ricerca sul Cancro; Cancer Research UK; Ministère des Affaires Sociales et de la Santé; Deutsche Forschungsgemeinschaft; Agenzia Italiana del Farmaco, Ministero della Salute; Academy of Medical Sciences","keywords":"Mitotane; Medicine; Adrenocortical carcinoma; Clinical endpoint; Observational study; Adjuvant; Internal medicine; Intention-to-treat analysis; Randomized controlled trial; Surgery; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006756066,0.0002585801,0.0008901198,0.0001588743,0.0001096375,0.00005559484,0.0005729807,0.00006878607,0.0001166854],"category_scores_gemma":[0.0007049256,0.0001850135,0.0000473881,0.0004276524,0.0002391647,0.0001653206,0.0003087505,0.0003973882,0.00004285836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000697933,"about_ca_system_score_gemma":0.0001075108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001370734,"about_ca_topic_score_gemma":0.0002565179,"domain_scores_codex":[0.9971704,0.0004484944,0.0005682501,0.000531405,0.0003092193,0.0009721962],"domain_scores_gemma":[0.9979454,0.001141521,0.0001380691,0.0005126125,0.00009677678,0.0001655755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4337476,0.005604409,0.5430115,0.00006827465,0.0006111025,0.004682011,0.001049396,0.00008702718,0.0007651809,0.001237455,0.00150561,0.007630425],"study_design_scores_gemma":[0.5943812,0.002364048,0.3933524,0.00002717892,0.00009087478,0.00006158047,0.0003849377,0.008366712,0.000168249,0.00009917549,0.0005038873,0.0001996657],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915786,0.0002897341,0.000002174434,0.004286563,0.001001635,0.002515787,0.00007470876,0.0001059422,0.000144869],"genre_scores_gemma":[0.9976559,0.00009846709,0.00006312576,0.0005968714,0.0007355583,0.0003953876,0.0002971697,0.00002821488,0.0001292742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1606336,"threshold_uncertainty_score":0.7544632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.189676285825029,"score_gpt":0.4136935625130954,"score_spread":0.2240172766880664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}