{"id":"W4386024385","doi":"10.1097/01.hs9.0000969552.85501.cf","title":"P662: POST HOC ANALYSIS OF PATIENT RESPONSES BY T315I MUTATION STATUS FROM THE 3-YEAR UPDATE OF THE OPTIC TRIAL: A DOSE-OPTIMIZATION STUDY OF 3 STARTING DOSES OF PONATINIB","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Medicine; Internal medicine; Myeloid leukemia; Oncology; Clinical endpoint; Clinical trial; Dasatinib; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007704592,0.001439067,0.002812888,0.0004561928,0.0004005244,0.001413078,0.001102475,0.001525801,0.005383385],"category_scores_gemma":[0.006159547,0.0004330303,0.006469657,0.0005123565,0.0009523942,0.001399003,0.000732018,0.003845754,0.0008482117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008783667,"about_ca_system_score_gemma":0.001267007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006994332,"about_ca_topic_score_gemma":0.001448182,"domain_scores_codex":[0.9957935,0.002655366,0.0001761617,0.000518251,0.0003512594,0.0005054674],"domain_scores_gemma":[0.9932389,0.003193313,0.001615233,0.0008840238,0.000348674,0.0007197935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.962402,0.003858404,0.009902524,0.0002552565,0.004322529,0.00007071108,0.0001146363,0.002443048,0.003287798,0.00009462296,0.002415373,0.01083295],"study_design_scores_gemma":[0.3091405,0.5125394,0.1385803,0.00007542028,0.01247171,0.0003990254,0.0002684222,0.01000596,0.00746506,0.0006721676,0.008189122,0.000192878],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945577,0.000640665,0.0005316507,0.0002323222,0.0001162992,0.0005484447,0.00197251,0.00007215363,0.001328221],"genre_scores_gemma":[0.9918349,0.0002375064,0.0008081154,0.000389792,0.0001995362,0.0009910825,0.003367547,0.00005754209,0.002114035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007704592,"threshold_uncertainty_score":0.04074621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797731521387673,"score_gpt":0.2869151710919347,"score_spread":0.268937855878058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}