{"id":"W4386024385","doi":"10.1097/01.hs9.0000969552.85501.cf","title":"P662: POST HOC ANALYSIS OF PATIENT RESPONSES BY T315I MUTATION STATUS FROM THE 3-YEAR UPDATE OF THE OPTIC TRIAL: A DOSE-OPTIMIZATION STUDY OF 3 STARTING DOSES OF PONATINIB","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Medicine; Internal medicine; Myeloid leukemia; Oncology; Clinical endpoint; Clinical trial; Dasatinib; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436471,0.0001560844,0.000598155,0.00011669,0.00005392397,0.000005921792,0.0001362595,0.00006211622,0.0003806898],"category_scores_gemma":[0.00103522,0.00009586232,0.0001961106,0.001653649,0.00009423721,0.00005566921,0.00009208189,0.00009581234,0.000002169784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560167,"about_ca_system_score_gemma":0.0003172597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002231285,"about_ca_topic_score_gemma":0.0003682983,"domain_scores_codex":[0.9975919,0.0003705527,0.00091316,0.0002429393,0.0006997082,0.0001817524],"domain_scores_gemma":[0.9970034,0.0009628058,0.001005871,0.0006354619,0.0003495395,0.00004291785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1697337,0.01063115,0.3060755,0.0008719227,0.0248854,0.00007318713,0.1209292,0.2930516,0.05232897,0.0001573073,0.002975079,0.01828706],"study_design_scores_gemma":[0.1855193,0.02033574,0.3610005,0.001390352,0.02371934,0.000003632428,0.2579933,0.06356399,0.08550485,0.0001189665,0.00017672,0.0006732438],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974923,0.0003379572,0.0000162881,0.0001543625,0.00006444367,0.001346114,0.0004967162,0.00002339577,0.00006839292],"genre_scores_gemma":[0.9987063,0.00006804325,0.0007130255,0.00002635639,0.00001262069,0.00003723076,0.0003285389,0.00002453973,0.0000833805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2294876,"threshold_uncertainty_score":0.4168286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797731521387673,"score_gpt":0.2869151710919347,"score_spread":0.268937855878058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}