{"id":"W4386024524","doi":"10.1097/01.hs9.0000968592.70537.d0","title":"P421: TARGETED DISRUPTION OF HUMAN FLT3 ERADICATES LEUKEMIC STEM CELLS WITHOUT HARMING HEALTHY HEMATOPOIETIC STEM CELLS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Stem cell; Haematopoiesis; Leukemia; Cancer research; Bone marrow; Myeloid leukemia; Biology; Immunology; Xenotransplantation; Hematopoietic stem cell; Transplantation; Medicine; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007231688,0.0004158459,0.0009533588,0.000265789,0.0002530139,0.00003734314,0.0003610839,0.0003076943,0.0006564561],"category_scores_gemma":[0.00001552073,0.000377035,0.0002520203,0.001144418,0.0002382357,0.0001616457,0.0002122053,0.0007422719,0.001173533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007905239,"about_ca_system_score_gemma":0.0005871768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001788538,"about_ca_topic_score_gemma":0.00002009317,"domain_scores_codex":[0.9961929,0.0001975606,0.0009248341,0.000735668,0.0009614141,0.0009875942],"domain_scores_gemma":[0.9977915,0.0002219645,0.0003435731,0.0009229599,0.0002196635,0.0005003007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003415116,0.0001979045,0.007301355,0.003509667,0.0001750423,0.0002384712,0.002390497,0.0001057138,0.9590603,0.0002196711,0.02321994,0.003239964],"study_design_scores_gemma":[0.004820644,0.0009934678,0.002167697,0.001086001,0.0001953731,0.0001186912,0.006795938,0.005323706,0.9740825,0.0001150392,0.003718242,0.0005826918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99482,0.001084876,0.0001584856,0.0007293734,0.000259699,0.001283684,0.00004069077,0.0004989657,0.001124231],"genre_scores_gemma":[0.9820831,0.0003213886,0.0004766922,0.0002049003,0.0002360544,0.0001005393,0.00007505217,0.0001596165,0.01634259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01950169,"threshold_uncertainty_score":0.9998682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03972043063278113,"score_gpt":0.3205576568430557,"score_spread":0.2808372262102746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}