{"id":"W4386024691","doi":"10.1097/01.hs9.0000968580.70418.79","title":"P418: DELE1 LOSS AND DYSFUNCTIONAL INTEGRATED STRESS SIGNALING IN TP53 MUTATED AML IS A NOVEL PATHWAY FOR VENETOCLAX RESISTANCE","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Venetoclax; Myeloid leukemia; Cancer research; Cytarabine; Leukemia; MCL1; Integrated stress response; Biology; Medicine; Chronic lymphocytic leukemia; Internal medicine; Gene; Genetics; Downregulation and upregulation; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799451,0.0002611418,0.0002798303,0.0002288198,0.0001462002,0.0003187304,0.0001721137,0.00022944,0.002306975],"category_scores_gemma":[0.0001709996,0.0001054151,0.0001527092,0.0002146173,0.0001995698,0.0001195028,0.0001910662,0.0003818523,0.0002874131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497756,"about_ca_system_score_gemma":0.000162165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000150487,"about_ca_topic_score_gemma":0.0002646867,"domain_scores_codex":[0.9998875,0.00001792094,0.000007538764,0.00003730139,0.00003100494,0.00001882571],"domain_scores_gemma":[0.9998815,0.00001753902,0.00006520415,0.00001067315,0.000006164335,0.00001882389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004090999,0.0003046274,0.06046794,0.0002188199,0.00007517553,0.00209327,0.00009230986,0.0009003397,0.8915142,0.0004955768,0.0009937977,0.038753],"study_design_scores_gemma":[0.0005198503,0.005437917,0.5361428,0.00007907113,0.0003589949,0.02460915,0.0002135926,0.005440676,0.4093405,0.0009473088,0.01687374,0.00003645306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968457,0.0009284686,0.0008077483,0.00006337611,0.000007974341,0.00003836597,0.0004907036,0.00005281256,0.0007648384],"genre_scores_gemma":[0.9985211,0.0002840458,0.0003400274,0.00002863545,0.000005308354,0.00002120994,0.0004278065,0.000006874488,0.0003648817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306975,"threshold_uncertainty_score":0.00771755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03089501745174479,"score_gpt":0.2949990361260349,"score_spread":0.2641040186742901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}