{"id":"W4386024691","doi":"10.1097/01.hs9.0000968580.70418.79","title":"P418: DELE1 LOSS AND DYSFUNCTIONAL INTEGRATED STRESS SIGNALING IN TP53 MUTATED AML IS A NOVEL PATHWAY FOR VENETOCLAX RESISTANCE","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Venetoclax; Myeloid leukemia; Cancer research; Cytarabine; Leukemia; MCL1; Integrated stress response; Biology; Medicine; Chronic lymphocytic leukemia; Internal medicine; Gene; Genetics; Downregulation and upregulation; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003648188,0.0002202328,0.0003671617,0.0001520203,0.0001061127,0.00003584799,0.0001142872,0.0001957302,0.0003259954],"category_scores_gemma":[0.0003322891,0.0001976262,0.00007432223,0.001002761,0.0001185432,0.00009168006,0.00007097868,0.0004221137,0.00005228422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006088196,"about_ca_system_score_gemma":0.0008361755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000188737,"about_ca_topic_score_gemma":0.0004720783,"domain_scores_codex":[0.9981765,0.00003613985,0.0003561831,0.0005048664,0.0003810502,0.0005452233],"domain_scores_gemma":[0.9988638,0.0003332925,0.00007160447,0.0002635077,0.0002838596,0.0001840052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0155381,0.0007909659,0.0761003,0.006928741,0.001101371,0.003009504,0.006729493,0.002768363,0.7375064,0.00427511,0.1261549,0.01909676],"study_design_scores_gemma":[0.06089089,0.002016664,0.07770459,0.008702265,0.0003460271,0.000423875,0.01691956,0.2052504,0.4311662,0.004421095,0.1894245,0.002733929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943104,0.0005352083,0.001585724,0.001413665,0.00008735815,0.0009608354,0.0003731382,0.0001733457,0.000560341],"genre_scores_gemma":[0.9810975,0.00007966819,0.004031372,0.0004365473,0.0001822503,0.0002977162,0.0005210466,0.00008636045,0.01326755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3063402,"threshold_uncertainty_score":0.8058963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03089501745174479,"score_gpt":0.2949990361260349,"score_spread":0.2641040186742901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}