{"id":"W4386033450","doi":"10.1186/s13287-023-03434-0","title":"Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Retinal degeneration; Retina; Retinal pigment epithelium; Biology; Transgene; Transplantation; Photoreceptor cell; Cell biology; Retinal; Stem cell; Muller glia; Genetically modified mouse; Embryonic stem cell; Genetic enhancement; Immunology; Neuroscience; Genetics; Internal medicine; Medicine; Gene; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001935423,0.0002353906,0.000255715,0.0003210028,0.0001579552,0.00005779594,0.000456377,0.0001851531,0.00007208261],"category_scores_gemma":[0.00001905676,0.0002182988,0.0001209389,0.0004961306,0.0001947313,0.00001119686,0.0002452999,0.0002998393,0.00004091303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005681016,"about_ca_system_score_gemma":0.0003356197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001064968,"about_ca_topic_score_gemma":0.00002507296,"domain_scores_codex":[0.997004,0.0004017396,0.0004257913,0.0005855215,0.0007590431,0.0008238668],"domain_scores_gemma":[0.9990576,0.00005023575,0.0001105729,0.0004619544,0.0001828693,0.0001367567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007890956,0.0001616712,0.0007960334,0.00009380603,0.00002308059,0.000003968889,0.0009602552,0.0006749663,0.9908525,0.000008399352,0.003037709,0.002598523],"study_design_scores_gemma":[0.00131977,0.0005724703,0.00007872215,0.00006782244,0.000001506791,3.591316e-7,0.001023666,0.001648317,0.9888926,0.0001410145,0.006012535,0.0002412686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993952,0.000616012,0.0001949554,0.0001370806,0.00008155059,0.001096188,0.00002360989,0.00002860004,0.003869943],"genre_scores_gemma":[0.9765338,0.00680955,0.0006761545,0.00003674607,0.00005510823,0.0003187369,0.00008011175,0.00006460126,0.01542515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01741822,"threshold_uncertainty_score":0.8901966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05746853304824676,"score_gpt":0.3137018180440824,"score_spread":0.2562332849958356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}