{"id":"W4386033544","doi":"10.1038/s42255-023-00855-2","title":"Glutarate regulates T cell metabolism and anti-tumour immunity","year":2023,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Evelyn Trust; Lister Institute of Preventive Medicine; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Directorate for Biological Sciences; Queen's University; Barncancerfonden; Cancerfonden; Wellcome Trust; Vetenskapsrådet; Government of Canada; Canadian Institutes of Health Research; Wellcome","keywords":"Catabolism; Metabolism; Chemistry; Biochemistry; Enzyme; Cell; Protein subunit; Cell metabolism; Amino acid; T cell; Function (biology); Metabolic intermediate; Cell biology; Biology; Immune system; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000751459,0.0004189219,0.0007190671,0.0003557151,0.0004262807,0.00005262324,0.0005400198,0.001111223,0.0005049561],"category_scores_gemma":[0.0001420186,0.0003603422,0.0001718954,0.0007823466,0.0003706063,0.0002111785,0.000417507,0.002039764,0.00153208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002010894,"about_ca_system_score_gemma":0.00007664362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009970256,"about_ca_topic_score_gemma":0.000005459809,"domain_scores_codex":[0.9977456,0.0004090521,0.0004032458,0.0005643278,0.00009940336,0.0007783622],"domain_scores_gemma":[0.9987178,0.0002050487,0.0001894794,0.0006877273,0.00015362,0.00004634236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006612772,0.00004998197,0.0001348251,0.00003924907,0.0001771292,0.00001505558,0.0005821272,0.00001383845,0.9738936,0.002434255,0.01987535,0.002718408],"study_design_scores_gemma":[0.001213611,0.000008870185,0.0559058,0.00001307834,0.0001371026,0.00003636448,0.0001261722,0.000005298764,0.531078,0.0008676139,0.4103046,0.0003034576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7979851,0.1920774,0.000004129043,0.0005213293,0.006045207,0.0002659598,0.00007542821,0.000363587,0.002661777],"genre_scores_gemma":[0.9801478,0.005097833,0.0001769776,0.0005786231,0.0002139192,0.00003093321,0.0001990741,0.00006832747,0.01348655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4428156,"threshold_uncertainty_score":0.9998848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006778699968401726,"score_gpt":0.2374942909281485,"score_spread":0.2307155909597468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}