{"id":"W4386033546","doi":"10.1038/s41593-023-01410-8","title":"A stable and replicable neural signature of lifespan adversity in the adult brain","year":2023,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Child Abuse and Trauma","field":"Psychology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Drug Abuse; Fondation pour la Recherche Médicale; Horizon 2020 Framework Programme; National Institute of Mental Health; National Institute for Health and Care Research; National Institute on Aging; Fédération pour la Recherche sur le Cerveau; National Natural Science Foundation of China; Institut National de la Santé et de la Recherche Médicale; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Wellcome Trust; Agence Nationale de la Recherche; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; Science Foundation Ireland; Medical Research Council; Universität Heidelberg; European Commission; Deutsche Forschungsgemeinschaft; King's College London; Fondation de France; Bundesministerium für Bildung und Forschung; South London and Maudsley NHS Foundation Trust; National Institutes of Health","keywords":"Psychology; Psychopathology; Brain size; Anxiety; Brain morphometry; Brain Structure and Function; Association (psychology); Neuroimaging; Developmental psychology; Normative; Cohort; Neuroscience; Neural correlates of consciousness; Clinical psychology; Ventral striatum; Cognition; Psychiatry; Striatum; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004280779,0.0001660828,0.0001363693,0.0003657654,0.0001687504,0.0002805374,0.0002389795,0.0001255558,0.0007285446],"category_scores_gemma":[0.001486279,0.0001034436,0.0001517965,0.0002097921,0.0003189444,0.0002598327,0.0003265696,0.0002404202,0.00009167556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002606435,"about_ca_system_score_gemma":0.0002281799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006790524,"about_ca_topic_score_gemma":0.01672143,"domain_scores_codex":[0.9999106,0.0000217483,0.000004676148,0.00003699171,0.00001326358,0.00001276212],"domain_scores_gemma":[0.9996449,0.00006584024,0.0001298063,0.00008685543,0.00003414396,0.00003842443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001222611,0.00002488222,0.9697106,0.00002490379,0.0001539958,0.0001850263,0.0003583613,0.003481353,0.01294752,0.000729295,0.0002386151,0.01202314],"study_design_scores_gemma":[9.407766e-7,0.00005812857,0.9960426,0.000005287215,0.00001465818,0.0002351005,0.0001145197,0.002088952,0.0006696619,0.0005690337,0.000197536,0.00000360021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982495,0.00007552902,0.001200215,0.00001162996,0.000001538747,0.00000195603,0.0002336926,0.000006995308,0.0002188777],"genre_scores_gemma":[0.9993705,0.00003726462,0.0003183759,0.000002796139,6.563105e-7,0.000002163986,0.0002094967,0.000001869949,0.0000567938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006790524,"threshold_uncertainty_score":0.013502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648814774379831,"score_gpt":0.2994708539828469,"score_spread":0.2829827062390486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}